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TranscriptomicsMLL regulated genes in LSK/CD48- hematopoietic stem cells
The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-47205 | biostudies-arrayexpress
GenomicsCopy Number Variation in Congenital Kidney Malformations

We report a study of large rare, copy number variants (CNVs) in 192 patients with renal hypodysplasia (RHD). Congenital malformations of the kidney and urinary tract are present in 3 to 7 per 1,000 births, accounting for 16% of birth defects. These malformations account for 40-50% of pediatric an...

phs000565.v1.p1 | EGA
UnknownAngiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use.
Not available
S-EPMC7856533 | biostudies-literature
UnknownAntibody Levels From High-Throughput Variant-Specific SARS-CoV-2 Anti-Spike Immunoglobulin G and Angiotensin-Converting Enzyme 2 Neutralization Assays Correlate With COVID-19 Infection Risk in a Large Population.
Not available
S-EPMC11998568 | biostudies-literature
TranscriptomicsWnt & LIF signalling in mESC
The molecular processes underlying the properties of ESC are yet unknown even when it's well established that LIF/STAT3 is neccesary for the maintenance of pluripotency. Other pathways as Wnt are may be implicated in the regulation of the biological mechanisms in mESC. Work model: D3-ES cultivated w...
ORGANISM(S): Mus musculus 
2009-12-30 | E-GEOD-11628 | biostudies-arrayexpress
UnknownEffect of Cancer Pain Guideline Implementation on Pain Outcomes Among Adult Outpatients With Cancer-Related Pain: A Stepped Wedge Cluster Randomized Trial.
Not available
S-EPMC8861847 | biostudies-literature
TranscriptomicsSubtractive Hybridization Reveals Novel Genes Associated with D. melanogaster Early Embryogenesis.
Background: The early stages of D. melanogaster embryogenesis involve cell migration and pattern formation, and lead to the formation of three germ layers (the ectoderm, mesoderm and endoderm). These developmental events are controlled by differential gene activity. In the current study we used a su...
ORGANISM(S): Drosophila melanogaster 
2010-05-16 | E-GEOD-15000 | biostudies-arrayexpress
TranscriptomicsExpression data from murine Hemophagocytes (HPCs) versus resting splenic macrophages
Hemophagocytes are activated macrophages seen morphologically to have engulfed other hematopoietic cells. Their function is unknown. Attempts to induce these cells in vitro or purify them ex vivo have been unsuccessful. We isolated HPCs and resting splenic macrophages by laser capture microdissectio...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-47430 | biostudies-arrayexpress
TranscriptomicsRecurrent disruption of HIP1 identified in patients with epilepsy, learning difficulties, intellectual disability, and neurobehavioral abnormalities
We report 12 individuals from ten unrelated families with epilepsy, learning difficulties, intellectual disability, and neurobehavioral abnormalities, who segregated a microdeletion distally adjacent to the Williams-Beuren syndrome region. In six families, a recurrent ~ 1.1 Mb deletion likely result...
ORGANISM(S): Homo sapiens 
2010-08-28 | E-GEOD-23834 | biostudies-arrayexpress
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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