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TranscriptomicsImmunoregulatory actions of T cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20523 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spleen after immunized using LPS vs MPL as adjuvant.
An unresolved issue in immunology is the extent to which inflammatory effects are needed for robust T cell responses. In this study, mice were immunized by iv injection using either high toxicity lipopolysaccharide (LPS) or low toxicity monophosphoryl lipid A (MPL) as adjuvant. Six hours after iv ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7768 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of presenilin deficient DP thymocytes
Notch1 signaling is an important regulator of cell fate in early stages of T cell development. Because Notch receptors can function redundantly, we sought an approach for inhibiting all endogenous Notch signaling in thymocytes. Upon ligand engagement, Notch receptors undergo two successive proteo...
ORGANISM(S): Mus musculus 
2007-09-14 | E-GEOD-6590 | biostudies-arrayexpress
TranscriptomicsTranscriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer fatalities in Western societies, characterized by high metastatic potential and resistance to chemotherapy. Critical molecular mechanisms of these phenotypical features still remain unknown, thus hampering the development ...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-59761 | biostudies-arrayexpress
TranscriptomicsExpression data of leaves from transgenic barley expressing wheat Lr34 gene
The wheat gene Lr34 (Yr18/Pm38/Sr57/Ltn1) encodes a putative ABCG-type of transporter and is a unique source of disease resistance providing durable and partial resistance against multiple fungal pathogens. Lr34 has been found to be functional as a transgene in barley. We used microarrays to deciphe...
ORGANISM(S): Hordeum vulgare 
2015-07-01 | E-GEOD-64228 | biostudies-arrayexpress
UnknownComparison of in silico predicted Mycobacterium tuberculosis spoligotypes and lineages from whole genome sequencing data.
Not available
S-EPMC10345134 | biostudies-literature
TranscriptomicsEpigenetic events in early breast cancer
Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8007 | biostudies-arrayexpress
UnknownMuscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy.
Not available
S-EPMC3418517 | biostudies-literature
UnknownNatural climate solutions for the United States.
Not available
S-EPMC6235523 | biostudies-literature
TranscriptomicsscRNAseq of human fetal duodenum, 70 DPC
We performed single cell RNA sequencing (scRNA-seq) of human fetal duodenal tissue samples from a single individual biological specimen at 70 days post-conception (DPC). The data set is composed of cells from diverse intestinal lineages. Lineages captured include epithelium, mesenchyme, immune, neur...
ORGANISM(S): Homo sapiens 
2025-07-30 | E-MTAB-15358 | biostudies-arrayexpress
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