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ProteomicsProteomic profiling of CHO cell temperature shift
The reduction of cell culture temperature (i.e. temperature-shift) is a method used to extend the viability of some commercial cell culture processes and improve product quality. We utilised LC-MS/MS to profile the proteome in temperature shifted cells as well as those a normal physiological tempera...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2024-08-10 | PXD053492 | Pride
Temperature shift Recombinant therapeutic protein Biopharmaceutical manufacturing Chinese hamster ovary cells 
ProteomicsProteomic profiling of the exponential and stationary of phases of CHO cell culture.
A non-mAb producing CHO-K1GS cell line was cultured for 7 days, samples were acquired for proteomics at 96 h post-seeding when the cells were in exponential growth (n = 4) and at 168 h when the cells had entered stationary phase (n = 4).
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2024-08-10 | PXD053511 | Pride
Growth phase Recombinant therapeutic protein Biopharmaceutical manufacturing Chinese hamster ovary cells 
ProteomicsHost cell protein detection in antibody drug products
Detection and quantitation of host cell proteins in six antibody drug products using data dependent acquisition LC-MS/MS
ORGANISM(S): Cricetus cricetus 
2024-08-10 | PXD053529 | Pride
Drug product Recombinant therapeutic protein Biopharmaceutical manufacturing Chinese hamster ovary cells 
TranscriptomicsCorneal Gene Expression Analysis
Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-56421 | biostudies-arrayexpress
TranscriptomicsAn Invasive Gene Expression Signature in Pancreas Cancer
Gene expression profiling has demonstrated clinical utility as a predictive tool in clinical oncology. We have identified genes associated with invasion of pancreatic cancer, and with potential for identifying early recurrence. We used Affymetrix Human U133 Plus 2.0 microarrays to identify specific ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22973 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Chinese Hamster Ovary production cell lines
The dataset set consists of 295 microarrays from 121 individual CHO cultures producing a range of biologics including monoclonal antibodies, fusion proteins and therapeutic factors; non-producing cell lines were also included. Samples were taken from a wide range of process scales and formats that v...
ORGANISM(S): Cricetulus griseus 
2011-07-27 | E-GEOD-30321 | biostudies-arrayexpress
TranscriptomicsBreast Cancer Gene Expression Analysis
Analysis of 104 breast cancer biopsies (removed prior to any treatment with tamoxifen or chemotherapeutic agents) from patients aged between 31 years and 89 years at the time of diagnosis (mean age = 58 years). Twenty were less than 50 years and seventy-seven women were 50 years, or older, at diagno...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42568 | biostudies-arrayexpress
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
ProteomicsSupporting raw MS data for paper (doi:10.1038/s41589-025-01894-4) by Raiff A., Zhao Z. et al (2025), titled "TOM20-Driven E3 Ligase Recruitment Regulates Mitochondrial Dynamics Through PLD6"
Supporting raw MS data for paper (doi:10.1038/s41589-025-01894-4) by Raiff A., Zhao Z. et al (2025), titled "TOM20-Driven E3 Ligase Recruitment Regulates Mitochondrial Dynamics Through PLD6". Index of MS files and labels Supplementary Table 1 - HEK293T - Proteome (CZ-1-23 | Unimod:35; 737; 4 | 126 -...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-23 | MSV000095689 | MassIVE
TranscriptomicsGene expression profiling of Fast vs. Slow Chinese Hamster Ovary cell lines using Wye3aHamster array
A 3rd generation Wye3aHamster microarray chip was used to carry out a differential expression microarray study of a panel of 30 slow- and fast-growing production cell lines, identifying a priority list of 240 transcripts (110 Up; 130 Down) that passed a statisical filter (ANOVA p-value <0.05, 1.3 f...
ORGANISM(S): Cricetulus griseus 
2013-01-01 | E-GEOD-37251 | biostudies-arrayexpress
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