Bulk RNA-seq profiling of untreated human cell lines derived from blood, breast and bladder tissues (MCF7, MDA-MB-231, KMCB2, Jurkat) to characterise baseline transcriptional differences across cellular contexts.
To identify disease-specific transcriptional programs in retinal pigment epithelium (RPE) cells, fibroblasts from 43 patients with geographic atrophy (GA) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into RPE and compared to those from 36 healthy individu...
