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ProteomicsCompartmentalized proteomic profiling outlines the crucial role of the Classical secretory pathway during recombinant protein production in Chinese hamster ovary cells
Chinese hamster ovary (CHO) cells have been widely employed for production of recombinant proteins (RP) for research and therapeutic purposes. Indeed, this expression system was used for production of most of approved antibodies (84%) in 2015-2018 period. The success of this cell line for RP product...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-05-04 | PXD021014 | Pride
Classical secretory pathway Subcellular fractionation Chinese hamster ovary cell Proteomics 
UnknownS100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
Not available
S-EPMC6366962 | biostudies-literature
UnknownCompartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells.
Not available
S-EPMC8154153 | biostudies-literature
UnknownInflammasome-Dependent Peroxiredoxin 2 Secretion Induces the Classical Complement Pathway Activation.
Not available
S-EPMC8568911 | biostudies-literature
ProteomicsAutophagic stress activates two distinct compensatory secretory pathways in neurons
Neurons are reliant on autophagy to constitutively degrade damaged proteins and organelles in order to maintain cellular homeostasis. Autophagic dysfunction is associated with neurodegenerative diseases including Parkinson Disease. Mutations in the kinase LRRK2 are one of the most common causes of f...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-24 | MSV000095428 | MassIVE
TranscriptomicsA lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Expression data from CD34+ hematopoietic cells transduced with control or anti-SLPI shRNA, serum starved and treated with G-CSF. CD34+ hematopoietic cells were isolated from the bone marrow of healthy individuals, transduced with lenitvirus-based RFP-expressed shRNA constructs targeting SLPI mRNA or...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-53353 | biostudies-arrayexpress
UnknownSaccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway.
Not available
S-EPMC2519769 | biostudies-literature
UnknownProtein release through nonlethal oncotic pores as an alternative nonclassical secretory pathway.
Not available
S-EPMC3217904 | biostudies-literature
TranscriptomicsDendritic cell-derived IL-2 promotes apoptosis of terminally mature cells via a novel autocrine signaling pathway
Dendritic cells (DCs) are crucial for sensing pathogens and triggering immune response. GM-CSF myeloid dendritic cells (GM-DCs) secrete several cytokines including IL-2 upon activation by pathogen associated molecular pattern (PAMP) ligands. DC IL-2 has been shown to be important for innate and adap...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-58120 | biostudies-arrayexpress
Unknownγ-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons.
Not available
S-EPMC3107561 | biostudies-literature
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