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UnknownQuantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia.
Not available
S-EPMC3397783 | biostudies-literature
TranscriptomicsTranscriptome analysis of TIML- and CIML-NK cells
NK cells may acquire under certain conditions features of adaptive immune cells. As the functional role of memory NK cells in cancer has so far remained elusive, we reasoned whether tumor-priming itself might promote memory NK cell generation. We provide substantial evidence that independent from pr...
ORGANISM(S): Homo sapiens 
2016-04-15 | E-MTAB-4606 | biostudies-arrayexpress
TranscriptomicsMurine bone marrow cells: Wild-type vs. PU.1 knockdown
Genome-wide screen for aberrant DNA methylation in bone marrow of PU.1 knockdown mice compared to control wildtype animals in three stages 7 age and gender matched mice pairs in the preleukemic stage, 5 pairs in the early leukemic stage and 7 pairs in the late leukemic stage
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-37315 | biostudies-arrayexpress
GenomicsDKFZ-HIPO Project H021/NCT MASTER
Clinical genome and transcriptome sequencing in younger adults with advanced-stage cancer across all histologies: DKFZ-HIPO Project H021 (http://www.hipo-heidelberg.org/hipo2/index.php/menu-item-2/32-021-prospective-genetic-characterization-of-tumors-from-individual-patients-of-special-interest) / N...
EGAS00001000948 | EGA
TranscriptomicsPRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells
Cord blood hematopoietic stem cells (CB-HSCs) are an outstanding source for transplantation approaches. However, the amount of cells per donor is limited and culture expansion of CB-HSCs is accompanied by a loss of engraftment potential. In order to analyze the molecular mechanisms leading to this i...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-58461 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-28-05-2015-11:13:32:451-82 - samples
Mutations that activate the RAF-MEK-ERK signaling pathway, in particular BRAFV600E, occur in many cancers, and mutant BRAF-selective inhibitors have clinical activity in these diseases. Activating BRAF alleles are usually considered to be mutually exclusive with mutant RAS, whereas inactivating muta...
EGAD00001001384 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-29-08-2014-08:27:40:831-1015 - samples
Whole-exome sequencing of a chronic lymphocytic leukemia (CLL) developed during vemurafenib treatment of a patient with malignant melanoma. Peripheral blood mononuclear cells were separated by Ficoll gradient centrifugation. DNA was extracted from highly purified (>97%) CD19+CD5+ cells obtained from...
EGAD00001000997 | EGA
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:37:32:058-207 - samples
RNA-seq of peripheral blood samples from CLL patients.
EGAD00001001675 | EGA
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:41:10:900-208 - samples
Tagmentation-based whole-genome bisulfite sequencing of isolated cell types from healthy controls.
EGAD00001001676 | EGA
Genomics450K_DKFZ_CLL_NB
CLL and normal B cell samples using 450K
EGAD00010000871 | EGA
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