Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of TIML- and CIML-NK cells

ABSTRACT: NK cells may acquire under certain conditions features of adaptive immune cells. As the functional role of memory NK cells in cancer has so far remained elusive, we reasoned whether tumor-priming itself might promote memory NK cell generation. We provide substantial evidence that independent from pro-inflammatory stimulation, tumor-induced memory-like (TIML) NK cells exhibit a heightened, tumor-restricted cytotoxicity which is dependent on a higher/faster perforin but not IFN-Î³ release. Comparative transcriptome analysis reveals that gene expression patterns differ between TIML- and Cytokine-induced memory-like (CIML)-NK cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Rainer Claus

PROVIDER: E-MTAB-4606 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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