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UnknownAdjuvant endocrine therapy for women with hormone receptor-positive breast cancer: american society of clinical oncology clinical practice guideline focused update.

Purpose

To update the ASCO clinical practice guideline on adjuvant endocrine therapy on the basis of emerging data on the optimal duration of treatment, particularly adjuvant tamoxifen.

Methods

ASCO convened the Update Committee and conducted a systematic review of randomized clinical...
S-EPMC4876310 | biostudies-literature
UnknownConservation Implications of Shifting Gut Microbiomes in Captive-Reared Endangered Voles Intended for Reintroduction into the Wild.
The Amargosa vole is a highly endangered rodent endemic to a small stretch of the Amargosa River basin in Inyo County, California. It specializes on a single, nutritionally marginal food source in nature. As part of a conservation effort to preserve the species, a captive breeding population was est...
S-EPMC6165168 | biostudies-literature
UnknownHow to specify healthcare process improvements collaboratively using rapid, remote consensus-building: a framework and a case study of its application.

Background

Practical methods for facilitating process improvement are needed to support high quality, safe care. How best to specify (identify and define) process improvements - the changes that need to be made in a healthcare process - remains a key question. Methods for doing so collaborat...
S-EPMC8111055 | biostudies-literature
UnknownDominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials.

Background

Clinical trial satisfaction is increasingly important for future trial designs and is associated with treatment adherence and willingness to enroll in future research studies or to recommend trial participation. In this post-trial survey, we examined participant satisfaction and a...
S-EPMC11364440 | biostudies-literature
UnknownSerial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.
The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial (11)C Pittsburgh compound B (PIB) positron emiss...
S-EPMC2677798 | biostudies-literature
UnknownCytogenetic prognostication within medulloblastoma subgroups.

Purpose

Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differ...
S-EPMC3948094 | biostudies-literature
UnknownSocial gradients in ADHD by household income and maternal education exposure during early childhood: Findings from birth cohort studies across six countries.

Objective

This study aimed to examine social gradients in ADHD during late childhood (age 9-11 years) using absolute and relative relationships with socioeconomic status exposure (household income, maternal education) during early childhood (<5 years) in seven cohorts from six industrialised...
S-EPMC8926184 | biostudies-literature
UnknownEarly family socioeconomic status and asthma-related outcomes in school-aged children: Results from seven birth cohort studies.

Objective

To examine the associations between maternal education and household income during early childhood with asthma-related outcomes in children aged 9-12 years in the UK, the Netherlands, Sweden, Australia, the USA and Canada.

Methods

Data on 31 210 children were obtained from 7...
S-EPMC11672016 | biostudies-literature
UnknownFXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist GSK2324 controls hepatic lipids via reduced absorption and selective decreases in fatty acid synthesis. Using comprehensive lip...
S-EPMC8353952 | biostudies-literature
UnknownEvaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.

Introduction

While the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) was ongoing, external data suggested higher doses were needed to achieve targeted effects; therefore, doses of gantenerumab were increased 5-fold, and solanezumab was increased 4-fold. We evaluated to what ex...
S-EPMC9632865 | biostudies-literature
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