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GenomicsMinor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition
PRJNA628709 | ENA
GenomicsMinor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.
PRJNA680751 | ENA
TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
ProteomicsProteome Alterations during Clonal Isolation of Human Pancreatic Cancer Cell Lines
Starting from an initial cell culture (Reference), three human pancreatic cancer cell lines (MIA PaCa-2, AsPC-1 and PANC-1) were either maintained by standard cell culture (Standard) or underwent clonal isolation to obtain single-cell colonies (SCC). Emerging cell pellets of five replicates per cond...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-23 | MSV000088904 | MassIVE
GenomicsAcquired TET2 mutation-linked clonal hematopoiesis in FPD/AML patient led to the development of pre-leukemic clone resulting independently in T2-ALL and AML-M0.
Germline RUNX1 mutations are found in familial platelet disorders with predisposition to acute myelogenous leukemia (FPD/AML). This very rare disease is characterized by thrombocytopenia, platelet dysfunction and a 35% lifetime risk of developing MDS/AML and in rare cases also T-ALL. Here, we focus ...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4679 | biostudies-arrayexpress
UnknownClonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis.
Not available
S-EPMC12342758 | biostudies-literature
UnknownMinor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.
Not available
S-EPMC8177065 | biostudies-literature
TranscriptomicsDiverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans Cell (LCH) and non-Langerhans (non-LCH) histiocytoses, respectively. The discovery of BRAFV600E mutations in ~50% of these patients pr...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-74442 | biostudies-arrayexpress
UnknownMechanisms of hematopoietic clonal dominance in VEXAS syndrome.
Not available
S-EPMC12176642 | biostudies-literature
TranscriptomicsAcquired TET2 mutation-linked clonal hematopoiesis in FPD/AML patient led to the development of pre-leukemic clone resulting independently in T2-ALL and AML-M0
Germline RUNX1 mutations are found in familial platelet disorders with predisposition to acute myelogenous leukemia (FPD/AML). This very rare disease is characterized by thrombocytopenia, platelet dysfunction and a 35% lifetime risk of developing MDS/AML and in rare cases also T-ALL. Here, we focus ...
ORGANISM(S): Homo sapiens 
2017-06-29 | E-MTAB-4623 | biostudies-arrayexpress
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