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Little is known of the genetic architecture of cancer at the subclonal and single cell level or in the stem-like cells responsible for cancer clone maintenance and propagation. We have examined this issue in ALL in which ETV6-RUNX1 gene fuson is an early or initiating genetic lesion followed by a mo...
ORGANISM(S): Homo sapiens 
Here, we use single cell sequencing to elucidate the role and heterogeniety of the bone marrow cells in clonal hematopoiesis. We have identified key CD74/CD206 macrophage populations that play a role in early clonal propagation of Tet2+/- cells and analyzed their expression at both week 1 and week 2...
ORGANISM(S): Mus musculus 
2026-05-15 | GSE314864 | GEO
Clonal propagation of Moniliophthora roreri and the emergence of unique lineages with distinct genomes during range expansion
Molecular characterization of clonal human renal forming cells
The adult kidney replaces lost cells in-vivo via proliferation of cells functioning as committed clonal progenitors. Here we combined the generation of single cell derived clonal cultures from human adult kidney with transcriptomic analysis for molecular characterization of in-vitro clonal behavior ...
ORGANISM(S): Homo sapiens 
2020-02-07 | GSE144908 | GEO
Tracing Clonal Hematopoiesis and Lymphoma-Associated Mutations in Hematopoietic Progenitors in B-Cell Non-Hodgkin Lymphoma (B-NHL)
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