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TranscriptomicsCfp1 is required for accurate H3K4me3 deposition in mouse ES cells
Trimethylation of histone H3 lysine 4 (H3K4me3) is a mark of active and poised promoters. The Set1 complex is responsible for most somatic H3K4me3 and contains the conserved subunit Cfp1, which binds to unmethylated CpGs and links H3K4me3 with CpG islands (CGIs). Here we report that Cfp1 plays unant...
ORGANISM(S): Mus musculus 
2012-07-04 | E-MTAB-1198 | biostudies-arrayexpress
GenomicsCfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells (ChIP-Seq)
Trimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependant manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in targeting the Set1 complex to CpG islands in mammals. In mou...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-53490 | biostudies-arrayexpress
TranscriptomicsCfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells (RNA-Seq)
Trimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependant manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in targeting the Set1 complex to CpG islands in mammals. In mou...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-53489 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis in normal and immortalised and transformed human cell lines
Analysis of expression changes in the fetal human lung fibroblast cell line MRC5 over time (two time points: 50 and 100 population doublings) during immortalisation with the catalytic component of telomerase (hTERT) and in vitro transformation with SV40 Large T antigen and oncogenic H-RAS
ORGANISM(S): Homo sapiens 
2013-11-11 | E-MTAB-2003 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of promoters in normal and immortalised and transformed human cell lines
Analysis of DNA methylation changes at promoters in the fetal human lung fibroblast cell line MRC5 over time (two time points: 50 and 100 population doublings) during immortalisation with the catalytic component of telomerase (hTERT) and in vitro transformation with SV40 Large T antigen and oncogen...
ORGANISM(S): Homo sapiens 
2013-11-11 | E-MTAB-2005 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblast cells transfected with a MDB-VP16 fusion to identify possible target genes for MBD1
We compared cells transfected with a MBD-VP16 fusion, with cells transfected with a control construct.
The purpose was to turn a repressor protein (MBD1) into an activator, and use differences in transcription to identify possible gene promoter targets.
A common reference was employed for all ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-MTAB-103 | biostudies-arrayexpress
TranscriptomicsChromatin compartmentalization regulates the response to DNA damage
DNA Double Strand Breaks (DSBs) repair is essential to safeguard genome integrity but little is known about the contribution of chromosome folding into these processes. Here we unveiled basic principles of chromosome dynamics occurring post-DSB both locally and at a genome wide scale in mammalian ce...
ORGANISM(S): Homo sapiens 
2023-11-17 | E-MTAB-10865 | biostudies-arrayexpress
UnknownA dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Not available
S-EPMC4413429 | biostudies-literature
TranscriptomicsMammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
Repair of DNA Double Strand Breaks produced in transcriptionally active chromatin occurs through a mechanism, Transcription-Coupled DSB repair (TC-DSBR), that is yet poorly characterized. Here, using a screening approach scoring multiple outputs in human cells, we identified the PER complex, a key m...
ORGANISM(S): Homo sapiens 
2025-11-12 | E-MTAB-12712 | biostudies-arrayexpress
GenomicsA dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells [ChIP-Seq]
Dendritic cells (DCs) direct CD4+ T cell differentiation into distinct T helper (Th) subsets that are vital for protection against diverse types of infection. However, the mechanisms employed by DCs to initiate Th2 responses, which are important for immunity to helminth infection as well as being a...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-66198 | biostudies-arrayexpress
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