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MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
TranscriptomicscRel sang
NF-kB is a transcriptional factor that consists in homo and heterodimers of the large family of Rel subunits. Among the most important functions for NF-kB, initiation of immunological/inflammatory responses and regulation of cell proliferation/apoptosis which are the major features of severe infecti...
ORGANISM(S): Mus musculus 
2011-10-14 | E-MEXP-2944 | biostudies-arrayexpress
UnknownVSIG4(+) peritoneal macrophages induce apoptosis of double-positive thymocyte via the secretion of TNF-α in a CLP-induced sepsis model resulting in thymic atrophy.
Not available
S-EPMC8139869 | biostudies-literature
ProteomicsHNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis
Constitutive androstane receptor (CAR) is a xenobiotic nuclear receptor mainly expressed in the liver, where it regulates drug metabolism and energy homeostasis. CAR has emerged as a promising therapeutic target for diabetes, fatty liver disease, and alcoholic liver disease, but it has not been inve...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD062961 | Pride
Lc-msms Clp-induced peritoneal sepsis Mouse Liver 
UnknownSepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency.
Not available
S-EPMC3972305 | biostudies-literature
TranscriptomicsNicotinamide mononucleotide administration triggers macrophages reprogramming and alleviates inflammation during sepsis induced by experimental peritonitis
Peritonitis and subsequent sepsis lead to high morbidity and mortality in response to uncontrolled systemic inflammation primarily mediated by macrophages. We investigated whether the administration of a natural biosynthetic precursor of NAD+, β-nicotinamide mononucleotide (β‐NMN), could prevent cli...
ORGANISM(S): Mus musculus 
2022-06-08 | GSE199156 | GEO
UnknownOverexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation.
Not available
S-EPMC7469348 | biostudies-literature
UnknownTLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity.
Not available
S-EPMC6715390 | biostudies-literature
GenomicsNicotinamide mononucleotide administration triggers macrophages reprogramming and alleviates inflammation during sepsis induced by experimental peritonitis
Nicotinamide mononucleotide administration triggers macrophages reprogramming and alleviates inflammation during sepsis induced by experimental peritonitis
PRJNA818667 | ENA
UnknownEarly enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival.
Not available
S-EPMC5540308 | biostudies-literature
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