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TranscriptomicsEffect of clp1 induction on rbf1-dependent gene regulation
The clp1 gene is a b-regulated gene that is required for clamp formation during the biotrophic growth phase of U. maydis. Interaction studies demonstrated that Clp1 imnteracts with Rbf1, the central regulator of pathogenciity. To exclude b-dependent effects the experiments were performed in a b-null...
ORGANISM(S): Ustilago maydis 
2010-09-17 | E-GEOD-21121 | biostudies-arrayexpress
TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
TranscriptomicstRNA fragment profiling in CLP1 mutant (kinase-dead) mice
Loss of CLP1 activity results in the accumulation of novel sets of small RNA fragments derived from aberrant processing of tyrosine pre-tRNA. Such tRNA fragments sensitize cells to oxidative stress-induced p53 activation and p53-dependent cell death. 2 samples, Wt and Clp1(k/k), no replicates
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-39275 | biostudies-arrayexpress
TranscriptomicsRNAseq of Ustilago maydis with inducible clp1 and Δcib1
Ustilago maydis strain JB1 was modified to include an arabinose inducible clp1 in the ip-locus and clb1 was deleted.
ORGANISM(S): Ustilago maydis 
2019-04-04 | E-MTAB-7463 | biostudies-arrayexpress
TranscriptomicsChIP-seq analysis of the Cib1 transcription factor with and without clp1 overexpression.
For ChIPseq analyses JB1 and UVO151 (JB1 Pcrg:clp1) were transformed with a Cib1-3xHA fusion construct was expressed under control of the endogenous promoter. The fusion construct was integrated at the endogenous locus replacing the native Cib1 gene.
ORGANISM(S): Ustilago maydis 
2019-04-04 | E-MTAB-7460 | biostudies-arrayexpress
TranscriptomicsEffect of clp1 induction on b-dependent gene regulation
The clp1 gene is a b-regulated gene that is required for clamp formation during the biotrophic growth phase of U. maydis. Clp1 expression blocks b-dependent filament formation and cell cycle arrest if co-induced with the b-heterodimer. Strains AB33 (control) and UMS84 were grown for the times indica...
ORGANISM(S): Ustilago maydis 
2011-03-30 | E-GEOD-21119 | biostudies-arrayexpress
GenomicsClp1 knockdown lentigenic mouse generation
Clp1 knockdown lentigenic mouse generation
PRJNA591193 | ENA
TranscriptomicsHuman CLP1 mutations alter tRNA biogenesis affecting both peripheral and central nervous system function
We elucidate a neurological syndrome affecting both the PNS and CNS defined by CLP1 mutations that impair tRNA splicing Identification and biochemical characterization of mutant CLP1 in human patients
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-53391 | biostudies-arrayexpress
GenomicsThe Cdc14 phosphatase, Clp1, does not affect genome expression
The Cdc14 phosphatase, Clp1, does not affect genome expression
PRJNA1073561 | ENA
GenomicsRNAseq of Ustilago maydis with inducible clp1 and Δcib1
RNAseq of Ustilago maydis with inducible clp1 and Δcib1
PRJEB30058 | ENA
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