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ProteomicsThe scaffold protein CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling
Cell motility is a critical feature of invasive tumour cells that is governed by complex signal transduction events. Particularly, the underlying mechanisms that bridge extracellular stimuli to the molecular machinery driving motility remain partially understood. Here, we show that the scaffold prot...
ORGANISM(S): Homo sapiens (Human) 
2023-04-20 | PXD038687 | Pride
Cancer cell motility Axl signaling Cnk2 
UnknownCNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.
Not available
S-EPMC10272126 | biostudies-literature
UnknownThe CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons.
Not available
S-EPMC4006347 | biostudies-literature
UnknownDisease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Not available
S-EPMC7109135 | biostudies-literature
TranscriptomicsGene Expression in White Adipose Tissue of KSR2-/- mice compared to wild type mice
The goal of this study was to define the gene expression changes that take place in the white adipose tissue of KSR2-/- mice at 6 months of age. Three wild type mice and three KSR2-/- mice were used for total RNA extraction from white adipose tissue. The RNA from each mouse was analyzed on one Affy...
ORGANISM(S): Mus musculus 
2009-09-03 | E-GEOD-17923 | biostudies-arrayexpress
UnknownFunctions of CNKSR2 and Its Association with Neurodevelopmental Disorders.
Not available
S-EPMC8774548 | biostudies-literature
TranscriptomicsDistinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts (Agilent 1-color)
Artificial epigenetic switches are of increasing demand owing to the critical role of the dynamic epigenome in orchestrating genome-wide transcriptional activation. Recently, we divulged that certain epigenetically active small molecules called SAHA-PIPs containing the cell permeable pyrrole-imidazo...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-53317 | biostudies-arrayexpress
TranscriptomicsDistinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts (Affymetrix)
Artificial epigenetic switches are of increasing demand owing to the critical role of the dynamic epigenome in orchestrating genome-wide transcriptional activation. Recently, we divulged that certain epigenetically active small molecules called SAHA-PIPs containing the cell permeable pyrrole-imidazo...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-53316 | biostudies-arrayexpress
TranscriptomicsDistinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts (Agilent 2-color)
Artificial epigenetic switches are of increasing demand owing to the critical role of the dynamic epigenome in orchestrating genome-wide transcriptional activation. Recently, we divulged that certain epigenetically active small molecules called SAHA-PIPs containing the cell permeable pyrrole-imidazo...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-53318 | biostudies-arrayexpress
TranscriptomicsTargeted inhibition of ubiquitin signaling reverses the metabolic reprogramming and suppresses Glioblastoma growth
Glioblastoma (GBM) is the most frequent and aggressive form of primary brain tumor in the adult population, and the high recurrence rate and resistance to current therapeutics urgently demand a better therapy for this disease. Regulation of protein stability by the ubiquitin proteasome system (UPS) ...
ORGANISM(S): Homo sapiens 
2022-06-29 | E-MTAB-11137 | biostudies-arrayexpress
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