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TranscriptomicsSex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells
Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory respons...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51707 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, harvested at peak of disease in EAE from CNS [EAE-CNS-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75107 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of Th17 cells, isolated from CNS or LN at peak of disease in EAE
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75105 | biostudies-arrayexpress
GenomicsTracking of CD4+ T cells during CNS autoimmunity
Tracking of CD4+ T cells during CNS autoimmunity
PRJNA658898 | ENA
GenomicsT:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
PRJNA1174079 | ENA
GenomicsTissue-resident memory CD4+ T cells sustain chronic CNS autoimmunity
Tissue-resident memory CD4+ T cells sustain chronic CNS autoimmunity
PRJNA1246655 | ENA
GenomicsTranscriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity [RNA-seq]
Transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity [RNA-seq]
PRJNA864797 | ENA
GenomicsTranscriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity [ATAC-seq]
Transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity [ATAC-seq]
PRJNA864793 | ENA
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, harvested at peak of disease in EAE from LN [EAE-LN-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75108 | biostudies-arrayexpress
GenomicsGenome-wide transcriptional analysis of CD8+ brain TRM during CNS autoimmunity
Genome-wide transcriptional analysis of CD8+ brain TRM during CNS autoimmunity
PRJNA783647 | ENA
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