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ProteomicsIdentifying overtraining biomarkers through proteomic analysis of extracellular vesicles derived from the central nervous system of male mice
Overtraining, which results in central nervous system (CNS)-fatigue-related symptoms, lead to a long-term decline in performance. This study investigated CNS-derived EV protein content under overtraining conditions to identify potential biomarkers. Eight-week-old C57BL/6J mice were randomly divided ...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD069257 | Pride
Biomarker Extracellular vesicle Cns-fatigue Overtraining Proteomic analysis 
ProteomicsProteomic Analysis of Cerebrospinal Fluids from Chronic Fatigue Syndrome Patients with and without Co-existing Fibromyalgia
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue. This has given rise to the question whether they are distinct central nervous system (CNS) entities or is one an extension of the other. To investigate th...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-09 | MSV000090685 | MassIVE
TranscriptomicsMetabolic and Skeletal Muscle Dysfunctions Correlate with Fatigue-Like Behavior in an Animal Model of Multiple Sclerosis
Multiple sclerosis associated fatigue (MS fatigue) is one of the most common and troubling symptoms experienced by people with MS, but the cause of MS fatigue remains unknown. The nature of cognitive and physical exhaustion suggests that MS fatigue can be a metabolic disease that impacts energy dema...
ORGANISM(S): Mus musculus 
2026-08-05 | GSE326115 | GEO
ProteomicsExercise Proteomics LPC mouse models
Exercise has the potential to significantly impact those suffering from autoimmune and inflammatory diseases including multiple sclerosis (MS). However, persons with multiple sclerosis (PwMS) do not engage in sufficient activity due to barriers such as increased fatigue, reduced mobility and disabil...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD020782 | Pride
Lpc Mouse Serum Multiple sclerosis Spinal cords 
UnknownRelationship between circadian activity rhythms and fatigue in hospitalized children with CNS cancers receiving high-dose chemotherapy.
Not available
S-EPMC7426544 | biostudies-literature
UnknownInfluence of Two Exercise Programs on Heart Rate Variability, Body Temperature, Central Nervous System Fatigue, and Cortical Arousal after a Heart Attack.
Not available
S-EPMC9819636 | biostudies-literature
GenomicsMetabolic and Skeletal Muscle Dysfunctions Correlate with Fatigue-Like Behavior in an Animal Model of Multiple Sclerosis
Metabolic and Skeletal Muscle Dysfunctions Correlate with Fatigue-Like Behavior in an Animal Model of Multiple Sclerosis
PRJNA1443394 | ENA
UnknownOral Bacteriotherapy Reduces the Occurrence of Chronic Fatigue in COVID-19 Patients.
Not available
S-EPMC8790565 | biostudies-literature
UnknownAn Investigation of the Effect of Exercise on Sleep Disturbances and Fatigue Symptoms in Patients Diagnosed with Primary Brain Tumors: A Systematic Review.
Not available
S-EPMC12821631 | biostudies-literature
UnknownBrainstem dose is associated with patient-reported acute fatigue in head and neck cancer radiation therapy.
Not available
S-EPMC5841457 | biostudies-literature
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