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MetabolomicsMulti-omics analysis of host airway responses in pediatric Mycoplasma pneumoniae pneumonia reveals potential mechanisms of disease exacerbation caused by co-infection

Respiratory viral co-infections in children with Mycoplasma pneumoniae pneumonia (MPP) are common and cause severe clinical manifestations. However, the exact pathogenic mechanisms of MPP co-infections are still unclear. In this study, we conducted a large-scale clinical analysis of 3,106 MPP pat...

2025-11-25 | MTBLS12635 | MetaboLights
MetabolomicsNMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection

Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operat...

2020-11-19 | MTBLS563 | MetaboLights
MetabolomicsOverexpression of tlr5 adrffects gut microbiota resistance to Salmonella infection

BACKGROUND: The gut microbiome and the host immune system interact synergistically to maintain intestinal health and defend against infections. Toll-like receptor 5 (TLR5), known for recognizing bacterial flagellin, plays a pivotal role in this regulatory network. Despite significant advances in ...

2024-07-25 | MTBLS10592 | MetaboLights
MetabolomicsElevated CO2 and virus infection impacts wheat and aphid metabolism

INTRODUCTION: The aphid Rhopalosiphum padi L. is a vector of Barley yellow dwarf virus (BYDV) in wheat and other economically important cereal crops. Increased atmospheric CO2 has been shown to alter plant growth and metabolism, enhancing BYDV disease in wheat. However, the bioch...

2019-01-16 | MTBLS622 | MetaboLights
MetabolomicsToxoplasma gondii infection induces metabolic alterations in the mouse cerebellum
Toxoplasma gondii is a protozoan parasite with a remarkable neurotropic affinity. We recently showed that T. gondii infection can alter the global metabolism of the cerebral cortex of the mice. However, the impact of this infection on the metabolism of the cerebellum remained unclear. In this study,...
2020-04-27 | MTBLS1537 | MetaboLights
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
MetabolomicsFecal metabolic changes in mice before Salmonella infection
With the monophasic variant of Salmonella Typhimurium (S. 4,[5],12:i-) emerging as one of the most prevalent serotypes, multidrug resistance has become an increasingly serious clinical challenge. Conventional antibiotic therapy is further constrained by adverse effects, including resistance selectio...
2026-10-04 | MTBLS15911 | MetaboLights
ModelsMukandavire2009 - Model for HIV-Malaria co-infection
Mathematical model for HIV, malaria and HIV-malaria co-infection.
2018-05-23 | MODEL1805230001 | BioModels
MetabolomicsHolistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging

A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histop...

2022-04-07 | MTBLS2671 | MetaboLights
MetabolomicsA gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection
The “gut-lung” axis is crucial for the chronic infection in bronchiectasis. However, the responsible microbe and the mechanism in the “gut-lung” axis of bronchiectasis are still in demand for precise elucidation. Here, we reported that Eggerthella lenta in the gut and taurine ursodeoxycholic acid (T...
2025-02-27 | MTBLS9522 | MetaboLights
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