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ProteomicsCo-translational assembly counteracts promiscuous interactions
During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiological relevance remains underexplored. Here, we exam...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-11 | PXD030626 | Pride
Co-translational assembly Proteomics 
GenomicsCo-translational assembly counteracts promiscuous interactions - addendum
Co-translational assembly counteracts promiscuous interactions - addendum
PRJEB50305 | ENA
ProteomicsCo-translational determination of quaternary structures in chaperone factories
The HSP90/R2TP quaternary chaperone assembles key cellular machines, including the three nuclear RNA polymerases and many non-coding RNPs. Here, we show that the R2TP binds many partners co-translationally. Remarkably, its co-translational interactome reveals many novel potential clients, and side-b...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD061298 | Pride
Translation factories Chaperone Co-translational assembly 
ProteomicsCo-translational assembly counteracts promiscuous interactions
During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiological relevance remains underexplored. Here, we exam...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-11 | PXD028413 | Pride
Protein complex assembly Co-translational assembly Nuclear pore complex 
TranscriptomicsWidespread Co-translational RNA Decay Reveals Ribosome Dynamics
It is generally assumed that mRNAs undergoing translation are protected from decay. Here, we show that mRNAs are, in fact, co-translationally degraded. This is a widespread and conserved process affecting most genes, where 5′–3′ transcript degradation follows the last translating ribosome, producing...
ORGANISM(S): Schizosaccharomyces pombe 
2015-06-04 | E-GEOD-63120 | biostudies-arrayexpress
GenomicsCo-translational determination of quaternary structures in chaperone factories
Co-translational determination of quaternary structures in chaperone factories
PRJNA1235270 | ENA
ProteomicsBacterial RF3 Senses Chaperone Function in Co-translational Folding
Molecular chaperones assist in protein folding by interacting with nascent polypeptide chains (NCs) during translation, but whether the ribosome can sense chaperone defects and abort translation of misfolding NCs has not been explored. Here we used quantitative proteomics in E. coli to investigate t...
ORGANISM(S): Escherichia coli 
2022-12-09 | PXD025219 | Pride
Molecular chaperones Co-translational folding 
GenomicsCo-translational binding of importins to nascent proteins
Co-translational binding of importins to nascent proteins
PRJEB53855 | ENA
GenomicsProteome-wide determinants of co-translational chaperone binding in bacteria
Proteome-wide determinants of co-translational chaperone binding in bacteria
PRJNA1238275 | ENA
GenomicsPELOTA and HBS1 suppress co-translational messenger RNA decay in Arabidopsis [GMUCT]
PELOTA and HBS1 suppress co-translational messenger RNA decay in Arabidopsis [GMUCT]
PRJNA1037109 | ENA
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