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MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
MetabolomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we fo...

2026-02-06 | MTBLS13473 | MetaboLights
MetabolomicsTranscript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
Mutton has recently been identified to be a consumer favorite, and intermuscular fat is the key factor in determining meat tenderness. Long-chain acyl-CoA synthetase 1 (ACSL1) is a vital subtype of the ACSL family that is involved in the synthesis of lipids from acyl-CoA and the oxidation of fatty a...
2023-02-06 | MTBLS5808 | MetaboLights
MetabolomicsMetabolomic profiling of Streptomyces coelicolor overexpressing the alpha subunit of acyl-CoA carboxylase
This study contains metabolomics data from Streptomyces coelicolor M145 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA precurso...
2026-05-06 | MTBLS14439 | MetaboLights
MetabolomicsMetabolomic profiling of Streptomyces virginiae overexpressing the alpha subunit of acyl-CoA carboxylase
This study contains metabolomics data from Streptomyces virginiae CGMCC 4.1619 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA p...
2026-05-06 | MTBLS14442 | MetaboLights
MetabolomicsMetabolomic profiling of Kitasatospora aureofaciens overexpressing the alpha subunit of acyl-CoA carboxylase
This study contains metabolomics data from Kitasatospora aureofaciens ATCC 10762 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA...
2026-05-06 | MTBLS14444 | MetaboLights
MetabolomicsMetabolomic profiling of Streptomyces ambofaciens overexpressing the alpha subunit of acyl-CoA carboxylase

This study contains metabolomics data from Streptomyces ambofaciens CGMCC 4.1528 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-...

2026-05-06 | MTBLS14441 | MetaboLights
Metabolomics2,3,7,8 -Tetrachlorodibenzo-p-dioxin Mediated Effects on Hepatic Coenzyme A (CoA) and Acetyl-CoA Levels (part-I)
Not available
ORGANISM(S): Mus musculus 
ST001376 | MetabolomicsWorkbench
Metabolomics2,3,7,8 -Tetrachlorodibenzo-p-dioxin Mediated Effects on Hepatic Coenzyme A (CoA) and Acetyl-CoA Levels (part-II)
Not available
ORGANISM(S): Mus musculus 
ST001379 | MetabolomicsWorkbench
MetabolomicsHypoxia promotes osteogenesis via regulating the acetyl-CoA-mediated mito-nuclear communication.
Not available
ORGANISM(S): Mus musculus 
ST002242 | MetabolomicsWorkbench
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