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ProteomicsMitochondrial content normalization using mass spectrometry allows quantitative evaluation of intrinsic bioenergetic efficiency and the underlying proteome across mouse organs.
To separate global changes to metabolism from intrinsic mitochondrial remodeling, investigators commonly use isolated mitochondrial preparations obtained through differential centrifugation. This simple process has been reliably implemented in a variety of tissues to produce intact, functional mitoc...
ORGANISM(S): Mus Musculus (mouse) 
2021-07-09 | PXD020280 | JPOST Repository
ProteomicsMitochondrial proteome of human leuekmia.
Proteome characterization of isolated mitochondria samples prepared from three commonly used acute leukemia cell lines (HL-60, KG-1, MV-4-11). Data were compared to isolated mitochondria prepared from peripheral blood mononuclear cells (PBMC), isolated from healthy human subjects.
ORGANISM(S): Homo Sapiens (human) 
2020-08-04 | PXD020715 | JPOST Repository
ProteomicsVincristine resistance reshapes sphingolipid composition and promotes mitochondrial complex I deficiency in acute myelogenous leukemia
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actio...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025645 | JPOST Repository
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