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TranscriptomicsGATA2 facilitates steroid receptor coactivator (SRC) recruitment to the androgen receptor (AR) complex
The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC), and frequently even after treatment with second-line hormonal therapies such as abiraterone and enzalutamide. The persistence of AR activity via both ligand-dependent and ligand-i...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-63539 | biostudies-arrayexpress
TranscriptomicsSteroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis
SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycoly...
ORGANISM(S): Homo sapiens 
2014-04-16 | E-GEOD-56843 | biostudies-arrayexpress
TranscriptomicsEffects of SPOP on gene expression in prostate cancer
SPOP is a ubiquitin ligase adaptor frequently mutated in prostate cancer. It is involved in ubiquitination and degradation of substrate proteins. We examined the impact of wild-type and mutant SPOP on the transcriptional profile of prostate cancer cells. We cloned several naturally occurring (in hum...
ORGANISM(S): Homo sapiens 
2014-10-10 | E-GEOD-59432 | biostudies-arrayexpress
TranscriptomicsIdentification of p38 beta as a therapeutic target for the treatment of Sézary Syndrome
Cutaneous T-Cell Lymphomas (CTCL) represent a group of hematopoietic malignancies that home to the skin and have no known molecular basis for disease pathogenesis. Sézary syndrome (SS) is the leukemic variant of CTCL. Currently, CTCL is incurable, highlighting the need for new therapeutic modalitie...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-59179 | biostudies-arrayexpress
GenomicsThe Human Gut Microbiome and Recurrent Abdominal Pain in Children

This project explores the nature of the human intestinal microbiome in healthy children and children with recurrent abdominal pain. The overall goal is to obtain a robust knowledge-base of the intestinal microbiome in children without evidence of pain or gastrointestinal disease, children with ...

phs000265.v3.p1 | EGA
TranscriptomicsImpact of Glucocorticoids and PI3K Inhibition on Gene Expression in Myeloma
We previously noted that combination glucocorticoids and PI3K inhibition induces synergistic cell death. To identify genes involved in myeloma cell death we examined mRNA expression in each individual treatment and in the combination. The glucocoriticoid resistant cells (MM.1RL) are used as a nega...
ORGANISM(S): Homo sapiens 
2015-12-07 | E-GEOD-64704 | biostudies-arrayexpress
TranscriptomicsDeciphering Cell-Specific Responses to Oncogenic Stress in the Liver
Each cell type responds uniquely to stress and fractionally contributes to global and tissue-specific stress responses. Hepatocytes, liver macrophages (M?), and sinusoidal endothelial cells (SEC) play functionally important and interdependent roles in adaptive processes such as wound healing, obesit...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-67225 | biostudies-arrayexpress
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