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TranscriptomicsExposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines
Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic, long term exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, as ...
ORGANISM(S): Rattus norvegicus 
2013-12-01 | E-GEOD-51207 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics of Daphnia magna exposed to a lithium cobalt oxide nanomaterial
Not available
ORGANISM(S): Daphnia magna 
ST001807 | MetabolomicsWorkbench
TranscriptomicsMycobacterial cells have dual nickel-cobalt sensors: sequence-relationships and metal-sites of metal-responsive repressors are not congruent.
A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterised from mycobacteria. Mutants of M. tuberculosis lacking kmtR show elevated expression of Rv2025c encoding a deduced CDF-family metal-exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviate...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-17 | E-BUGS-49 | biostudies-arrayexpress
UnknownBioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate.
Not available
S-EPMC7098370 | biostudies-literature
TranscriptomicsTranscription profiling of Hep3B cells response hypoxia (1%O2) and cobalt chloride (100 uM) and deferoxamine (100 uM) and Nickel Chloride (100 uM)
Comparison between hypoxia (1%O2) and cobalt chloride (100 uM) and deferoxamine (100 uM) and Nickel Chloride (100 uM) in Hep3B cells (human hepatocellular carcinoma cells)
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-1056 | biostudies-arrayexpress
TranscriptomicsRhodobacter sphaeroides 2.4.1 adaptation to high concentrations of Cobalt ions
To further characterize the capability of R. sphaeroides to cope with high cobalt ion concentrations, we combined the selection of adaptive defective mutants, carried out by negative selection of transposon insertional libraries on 5 mM Co2+ enriched solid medium, with the analysis of growing capaci...
ORGANISM(S): Rhodobavter sphaeroides strain 2.4.1 
2014-03-07 | E-MTAB-2284 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E.coli cells in the response to Cobalt stress
Analysis used RNA extracted from Escherichia coli exposed or not to cobalt. Experiments were done with E. coli MC4100 cultures exposed to CoCl2 (250 µM) in mid-exponential phase during 30 min. Comparisons were made across multiple arrays, using E. coli MC4100 DNA microarrays spotted with PCR product...
ORGANISM(S): Escherichia coli 
2010-03-01 | E-MEXP-2551 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of an evolutionary strain of Saccharomyces cerevisiae resistant to cobalt 10mM
We have employed whole genome microarray expression profiling as a discovery platform to identify genes implicated in the resistance to cobalt in Saccharomyces cerevisiae. The evolved strains and the wild type were harvested in exponential phase WT (CEN.PK), the evolved strain (CI25E) and the evolve...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-31 | E-GEOD-39185 | biostudies-arrayexpress
MetabolomicsDual metal electrolysis in theta capillary for lipid analysis

Increasing studies associating glycerophospholipids with various pathological conditions highlight the need for their thorough characterization. However, the intricate composition of the lipidome due to the presence of lipid isomers poses significant challenges to structural lipidomics. This stud...

2023-10-10 | MTBLS8547 | MetaboLights
TranscriptomicsTranscriptional profiling of lung tissue of rat pretreated with cobalt in normoxic and hypoxic conditions and comapring with saline treated normoxic and hypoxic lung tissue in different time interval
The goal of the study was to examine the effect of hypoxic preconditioning with cobalt on global gene profiling in lung tissues. Agilent two-color experiment,Organism: Rat ,Slides, Agilent’s Whole Rat Genome Microarray 4x44k GPL4135 with 44000 features, Labeling kit: Agilents Low input RNA linear ...
ORGANISM(S): Rattus norvegicus 
2010-05-27 | E-GEOD-21239 | biostudies-arrayexpress
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