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UnknownA new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma.
Not available
S-EPMC10517165 | biostudies-literature
TranscriptomicsCooperative blockade of CK2 and ATM kinases drives apoptosis in VHL-deficient renal carcinoma cells / RNA-seq (BRB-seq) of treated 786-O spheroids
Multicellular Tumor Spheroids (MCTS) were pre-formed for 3 days with 786-O cell line to better mimic the tumor microenviroenment. These spheroids were treated with either vehicle (DMSO), drugs alone (KU-60019 10 μM; CX-4945 5 μM) or in combination (KU + CX) for 48h before RNA extraction.
ORGANISM(S): Homo sapiens 
2021-02-04 | E-MTAB-9977 | biostudies-arrayexpress
TranscriptomicsDownregulation of CK2-Beta is sufficient to drive epithelial-to-mesenchymal transition through Snail 1 induction
To understand how CK2M-NM-2 silencing promotes a mesenchymal phenotype in human epithelial cells, like TGFM-NM-2 does, we have employed whole genome microarray expression profiling as a discovery platform to compare genes regulated in CK2M-NM-2-depleted cells and in TGFM-NM-2-treated cells. To do s...
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-28569 | biostudies-arrayexpress
TranscriptomicsGenome-scale analysis of Staphylococcus aureus reveals host-specific diversification of the core genome.
Staphylococcus aureus causes disease in humans and a wide array of animals. Of note, S. aureus mastitis of ruminants, including cows, sheep and goats, results in major economic losses worldwide. Extensive variation in genome content exists among S. aureus pathogenic clones. However, the genomic vari...
ORGANISM(S): Staphylococcus aureus 
2008-11-18 | E-GEOD-10187 | biostudies-arrayexpress
UnknownIn Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface.
Not available
S-EPMC5374420 | biostudies-literature
ProteomicsCK2β is a gatekeeper of focal adhesions regulating cell spreading
CK2 is an hetero-tetrameric protein made of two CK2α catalytic subunits and two regulatory CK2β subunits. The free CK2α subunit and the tetrameric holoenzyme have distinct substrate specificity profiles suggesting that the spatiotemporal organization of the individual CK2 subunits observed in living...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD030991 | Pride
Proteomics Tyrosine phosphorylated proteins Ck2β depletion Lc-ms/ms 
UnknownCorneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate.
Not available
S-EPMC4661092 | biostudies-literature
Unknown[123I]MIBG is a better early marker of anthracycline cardiotoxicity than [18F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study.
Not available
S-EPMC8452816 | biostudies-literature
UnknownA COL5A2 In-Frame Deletion in a Chihuahua with Ehlers-Danlos Syndrome.
Not available
S-EPMC9142074 | biostudies-literature
UnknownStem Cell-Like Properties of CK2β-down Regulated Mammary Cells.
Not available
S-EPMC5615329 | biostudies-literature
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