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ProteomicsIsolation and Comprehensive Analysis of Cochlear Tissue-derived Small Extracellular Vesicles
Label-free quantitative proteomics analysis of CDsEVs, with the same amount of protein of cochlear tissues used as the control
ORGANISM(S): Mus Musculus 
2024-10-04 | PXD056591 |
ProteomicsQuantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats
The cochlea, a sensitive biosensor, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may impair hearing. Mass spectrometry-based proteomics offers insights into protei...
ORGANISM(S): Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) 
2025-07-21 | PXD059025 | Pride
Mass-spectrometry Cochlear tissue Rat Proteomics Guinea pigs 
TranscriptomicsTranscription profiling of mouse with unilateral cochlear removal in Cochlear Nucleus at P7 and P21
Deprivation of peripheral nerve input by cochlear removal in young mice results in dramatic neuron death in the cochlear nucleus (CN). The same manipulation in older mice does not result in significant loss. The molecular basis of this critical period of vulnerability remains largely unknown. Her...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5394 | biostudies-arrayexpress
Genomicsmouse cochlear tissue derived small extracellular vesicle and cochlear tissue small RNA transcriptome
mouse cochlear tissue derived small extracellular vesicles and cochlear tissue small RNA transcriptome Raw sequence reads
PRJNA1168682 | ENA
TranscriptomicsTranscription profiling of cochleae from young and middle aged mice subjected to calorie restriction to examine age-related changes and calorie restriction-induced changes in gene expression in the cochlea.
Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea. Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late on...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4786 | biostudies-arrayexpress
TranscriptomicsTemporal profiling of gene expression in cochleae of wild type and alpha9 null mice
Efferent inhibition of cochlear outer hair cells is mediated by nicotinic cholinergic receptors containing alpha9 (a9) and alpha10 subunits. Mice lacking a9 nicotinic subunits fail to exhibit classic olivocochlear responses and are characterized by abnormal synaptic morphology at the base of outer ...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-18567 | biostudies-arrayexpress
TranscriptomicsA Human Fetal Cochlear Cell Atlas Reveals a Regulatory Blueprint for Spatial Patterning- scRNA-seq-2
Human cochlear organoids were derived from human pluripotent stem cell–based differentiation and maintained in CHIR99021-containing proliferative medium (EFI). Organoids were cultured under proliferative conditions for 10 days, after which they were transduced with 3 types of adeno-associated virus ...
ORGANISM(S): Homo sapiens 
2026-02-11 | E-MTAB-16612 | biostudies-arrayexpress
TranscriptomicsA Human Fetal Cochlear Cell Atlas Reveals a Regulatory Blueprint for Spatial Patterning - scRNA-seq
Human fetal cochleae were collected from 11-16 PCW donors (each n=2) and immediately preserved in ice-cold oxygenated artificial tissue preservation solution. Under microscopic guidance, the non-osseous cochlear tissues were meticulously dissected to expose internal structures. Tissue dissociation w...
ORGANISM(S): Homo sapiens 
2026-02-04 | E-MTAB-16336 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P21 cochlear nucleus after activity deprivation
We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity in the 8th nerve. Pharmacological activity blockade of the auditory nerve for 24 h resulted in similar expression changes for only a subset of genes. Thus, an a...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-11726 | biostudies-arrayexpress
TranscriptomicsIdentification of microRNA targets in the mammalian inner ear using a comprehensive transcriptome and proteome integrated approach
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions using integrated miRNA, transcriptome and proteome profiles with advanced in silico analysis. By looking at both the transcript and protein levels of expression, a thorough coverag...
ORGANISM(S): Mus musculus 
2011-04-20 | E-GEOD-23081 | biostudies-arrayexpress
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