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A general means of viral attenuation involves the extensive recoding of synonymous codons in the viral genome. The mechanistic underpinnings of this approach remain unclear, however. Using quantitative proteomics and RNA sequencing, we explore the molecular basis of attenuation in a strain of bacte...
ORGANISM(S): Enterobacteria phage T7 Escherichia coli (strain K12) 
2018-10-24 | PXD006502 | Pride
Mechanism of virus attenuation by codon pair deoptimization
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