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UnknownOligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay.
Not available
S-EPMC9411196 | biostudies-literature
ProteomicsDistinct ribosome states trigger diverse mRNA quality control pathways
Key protein adapters couple translation to mRNA decay on specific classes of problematic mRNAs in eukaryotes. Slow decoding on nonoptimal codons leads to codon-optimality-mediated decay (COMD) and prolonged arrest at stall sites leads to no-go decay (NGD). The identities of the decay factors underly...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-08 | PXD030076 | Pride
Comd Ngd Syh1 Rna decay Smy2 Codon-optimality-mediated decay No-go decay 
TranscriptomicsTranscriptional decay profiling of Neurospora crassa
Codon optimality mediated decay(COMD) is a conserved phenomenon from yeast to human. Our data suggests that COMD alson exist in neurospora crass. We resort thiolutin(inhibitor for transcription) to treat cells in different time point and transcriptionally profiled them to get the landscape of transp...
ORGANISM(S): Neurospora crassa 
2023-12-31 | GSE238077 | GEO
GenomicsTranscriptional decay profiling of Neurospora crassa
Transcriptional decay profiling of Neurospora crassa
PRJNA997929 | ENA
GenomicstRNA-seq of Arabidopsis leaves during pattern-triggered immunity
During pattern-triggered immunity (PTI), the first line of active defense against infection in plants, the translatome undergoes rapid reprogamming. To understand how defense proteins are selectively translated, we conducted a genetic screen for regulators of PTI using a translational reporter. We i...
ORGANISM(S): Arabidopsis thaliana 
2023-04-02 | GSE171411 | GEO
TranscriptomicsOligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [RiboSeq]
Oligodendrocytes are specialized cells that confer neuronal myelination. Leukodystrophies associated with oligodendrocyte and hypomyelination are known to result when a number of tRNA metabolism genes are mutated. Thus, for unknown reasons, oligodendrocytes may be hypersensitive to perturbations in ...
ORGANISM(S): Mus musculus 
2022-08-08 | GSE182810 | GEO
TranscriptomicsOligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [DecaySeq]
Oligodendrocytes are specialized cells that confer neuronal myelination. Leukodystrophies associated with oligodendrocyte and hypomyelination are known to result when a number of tRNA metabolism genes are mutated. Thus, for unknown reasons, oligodendrocytes may be hypersensitive to perturbations in ...
ORGANISM(S): Mus musculus 
2022-08-08 | GSE182809 | GEO
GenomicsOligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [QuantMseq]
Oligodendrocytes are specialized cells that confer neuronal myelination. Leukodystrophies associated with oligodendrocyte and hypomyelination are known to result when a number of tRNA metabolism genes are mutated. Thus, for unknown reasons, oligodendrocytes may be hypersensitive to perturbations in ...
ORGANISM(S): Mus musculus 
2022-08-08 | GSE182808 | GEO
GenomicsOligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [QuantM-seq II]
Oligodendrocytes are specialized cells that confer neuronal myelination. Leukodystrophies associated with oligodendrocyte and hypomyelination are known to result when a number of tRNA metabolism genes are mutated. Thus, for unknown reasons, oligodendrocytes may be hypersensitive to perturbations in ...
ORGANISM(S): Saccharomyces cerevisiae 
2022-08-08 | GSE198271 | GEO
GenomicsOligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [DecaySeq]
Oligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [DecaySeq]
PRJNA757961 | ENA
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