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MetabolomicsCD22 Blockade Alleviates Anesthesia Surgery-Mediated Cognitive Impairment in Aged Mice

Postoperative cognitive dysfunction (POCD) is a common complication characterized by cognitive decline following surgery, with neuroinflammation serving as a critical pathogenic mechanism. Emerging evidence indicates that CD22, an inhibitory receptor primarily expressed on B cells and microglia, ...

2025-09-24 | MTBLS13028 | MetaboLights
MetabolomicsUrine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease.

INTRODUCTION Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein ...

2024-01-11 | MTBLS8662 | MetaboLights
MetabolomicsGut Microbiota–Derived Ergothioneine Alleviates Antipsychotic-Induced Synaptic and Cognitive Impairments

Background: Chronic use of antipsychotic drugs is associated with neuronal damage and cognitive impairment, potentially mediated by alterations in gut microbiota metabolites, although the specific metabolite involved remains unknown.

Objective: To identify the key metabolite responsible for...

2026-04-08 | MTBLS12751 | MetaboLights
MetabolomicsAerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder. It is marked by motor dysfunction and cognitive decline. In recent years, scientific studies have found that PD's pathogenesis may be tied to an imbalance in the gut microbiota. This offers new perspectives for PD treatment. Modulat...

2025-10-12 | MTBLS13123 | MetaboLights
MetabolomicsExtracellular Vesicles from probiotics mediated Walnut green husk polysaccharide alleviates ochratoxin-A-induced cognitive impairment via SCFA and 5-HT mediated microbiota-gut-brain axis

BACKGROUND: Ochratoxin A (OTA) have made it a serious hazard to food safety worldwide that poses a serious health risk to humans. Our previous research showed that Walnut green husk polysaccharides (WGP) can effectively alleviate intestinal inflammation and intestinal microbiota ...

2024-10-10 | MTBLS10673 | MetaboLights
MetabolomicsGut microbial release of ferulic acid from germinated quinoa alleviates obesity-associated cognitive impairment via activation of PINK1/Parkin-mediated mitophagy in the hippocampus

Background Obesity is a major risk factor for cognitive impairment and related neurodegenerative disorders. Whole grains are rich in polyphenols and dietary fiber, and their consumption has been associated with improvements in obesity and cognitive deficits. Gut microbial genes encode enzymes tha...

2026-03-30 | MTBLS14185 | MetaboLights
TranscriptomicsEffect of Kurozu on hippocampal gene expression profiles in SAMP8
Kurozu is a traditional Japanese rice vinegar. During fermentation and aging of the Kurozu liquid in an earthenware jar over 1 year, solid residue called Kurozu Moromi is produced. In the present study, we evaluated whether concentrated Kurozu or Kurozu Moromi could ameliorate cognitive dysfunction ...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-70514 | biostudies-arrayexpress
TranscriptomicsDeep Sleep and Parietal Cortex Gene Expression Changes are Related to Cognitive Deficits with Age
Background: Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption’s well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep’s relationship to cogn...
ORGANISM(S): Rattus norvegicus 
2011-04-21 | E-GEOD-24515 | biostudies-arrayexpress
MetabolomicsBerberine improves intestinal barrier and cognitive impairment by remodeling intestinal microbiota in C57BL/6 septic mice induced by LPS
After feeding LPS induced C57BL/6 septic mice with berberine, we performed behavioral, HE staining, ELISA, western blot, metagenomic sequencing of gut microbiota and untargeted metabolomics analysis to evaluate the effects of berberine on septic mice.
2026-06-17 | MTBLS14775 | MetaboLights
ProteomicsPlasma proteome of mild cognitive impairment
Multiple Affinity Removal Spin Cartridge Human 14 kit (Agilent) was used to remove 14 major proteins from plasma. Samples were denatured with an equivalent volume of trifluoroethanol and reduced with dithiothreitol. Free cysteine residues were alkylated with iodoacetamide. Samples were incubated wi...
ORGANISM(S): Homo Sapiens (human) 
2022-05-11 | PXD025937 | JPOST Repository
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