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TranscriptomicsTranscription profiling of human squamous cell carcinoma of the head and neck cells reveals tumor growth and prognosis of squamous cell carcinoma of the head and neck is linked to protein kinase C alpha
Protein Kinase C alpha (PKC) is a critical mediator of cell signaling and cancer growth. We show that PKC inhibitors decrease proliferation in squamous cell carcinoma of the head and neck (SCCHN) cells and abrogate growth of SCCHN tumors in mouse xenografts. Analysis of gene expression arrays reveal...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10299 | biostudies-arrayexpress
TranscriptomicsGenes regulated by PCK Inhibitors, enzastaurin and Go, in CAL-27 cells, a SCCHN cell line
Efficacy of the Multi-Kinase Inhibitor Enzastaurin is Dependent on Cellular Signaling Context Testing a panel of SCCHN cell lines revealed variable sensitivity to enzastaurin which correlated significantly with baseline cyclin D1 protein expression. Moreover, sensitivity and resistance could be reve...
ORGANISM(S): Homo sapiens 
2010-07-12 | E-GEOD-22811 | biostudies-arrayexpress
UnknownPhase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer.
Not available
S-EPMC4876357 | biostudies-literature
UnknownComputational modeling of color perception with biologically plausible spiking neural networks.
Not available
S-EPMC9642903 | biostudies-literature
UnknownBeyond Content Delivery: A Systematic Review of Video-Based SRL Interventions and Gaps in Explicit Motivational and Resource-Management Instruction.
Not available
S-EPMC12942538 | biostudies-literature
TranscriptomicsTranscription profiling of human head and neck squamous cell carcinoma samples reveals a feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle
Patient selection and specimen collection. Thirty-six freshly frozen tumor samples were prospectively collected from patients undergoing surgery or biopsy for HNSCC at the University of North Carolina (UNC) at Chapel Hill (21 patients) and Vanderbilt University (15 patients). All tissues were snap-f...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10300 | biostudies-arrayexpress
UnknownCabozantinib in progressive medullary thyroid cancer.
Not available
S-EPMC4164813 | biostudies-literature
UnknownFetal Exposure to MR Imaging: Long-Term Neurodevelopmental Outcome.
Not available
S-EPMC7658847 | biostudies-literature
UnknownA single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium.
Not available
S-EPMC9995031 | biostudies-literature
UnknownResearch trends analysis of chronic hepatitis C versus nonalcoholic fatty liver disease: A literature review text-mining analysis of publications.
Not available
S-EPMC9674169 | biostudies-literature
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