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ProteomicsAssembly of a nuclear lamin coil 2 fragment
Nuclear structure and function are governed by lamins, which are intermediate filaments mostly consisting of α-helices. Different lamin assembly models have been proposed based on low resolution or fragmented structures. However, their assembly mechanisms at the molecular level are poorly understood...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD014029 | Pride
Human Coil 2 Lamin Nuclear protein 
GenomicsInhibition of Rho-associated, coiled-coil-containing protein kinase 2 in murine podocytes
Inhibition of Rho-associated, coiled-coil-containing protein kinase 2 in murine podocytes
PRJNA1090039 | ENA
GenomicsCUT&RUN seq of HSF4 and COIL after UV stimulation of NIH-3T3 cells
CUT&RUN seq of HSF4 and COIL after UV stimulation of NIH-3T3 cells
PRJNA977581 | ENA
TranscriptomicsEffects of depletion of Rho-associated, coiled-coil-containing protein kinase 2 in the kidney medullary tussue of murine model.
Rho and its effector Rho-associated, coiled-coil–containing protein kinase 2 (ROCK2) play crucial roles in a variety of cellular functions, such as cell adhesion and cytoskeletal rearrangement . We here investigated the role of ROCK2 in the kidney medullary tissue using tubular specific ROCK2 knocko...
ORGANISM(S): Mus musculus 
2024-07-01 | GSE246069 | GEO
GenomicsEffects of depletion of Rho-associated, coiled-coil-containing protein kinase 2 in the kidney medullary tussue of murine model.
Effects of depletion of Rho-associated, coiled-coil-containing protein kinase 2 in the kidney medullary tussue of murine model.
PRJNA1031226 | ENA
GenomicsCUT&RUN seq of HSF4 and COIL after UV stimulation of NIH-3T3 cells
Intense ultraviolet (UV) exposure can cause phototoxic reactions, such as skin inflammation, resulting in injury. UV is believed to be the direct cause of DNA damage, but the mechanisms of transcriptional regulation within cells after DNA damage are unclear. The bioinformatic analysis of transcripto...
ORGANISM(S): Mus musculus 
2023-08-08 | GSE233680 | GEO
ProteomicsStructural basis for assembly of lamin at the molecular level
Nuclear structure and function are governed by lamins, which are intermediate filaments mostly consisting of alpha-helices. Different lamin assembly models have been proposed based on low resolution or fragmented structures. However, their assembly mechanisms at the molecular level are poorly unders...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD013144 | Pride
Chemical crosslinking Nuclear lamin protein X-ray crystallography Gel-based lc-msms Filament assembly structure 
TranscriptomicsInhibition of Rho-associated, coiled-coil-containing protein kinase 2 in murine podocytes
Focal segmental glomerulosclerosis (FSGS) is characterized by damage to podocytes, a crucial pathological feature. While several mechanisms of podocyte injury have been suggested, many questions remain unanswered. Rho-associated, coiled-coil-containing protein kinase 2 (ROCK2), a serine/threonine ki...
ORGANISM(S): Mus musculus 
2024-03-20 | GSE262013 | GEO
GenomicsComparative evaluation of intein, AAVLINK, StichR, and coiled-coil ABE8e systems targeting endogenous genomic loci and at 2 engineered KCNQ2 target sites carrying different mutations.
Comparative evaluation of intein, AAVLINK, StichR, and coiled-coil ABE8e systems targeting endogenous genomic loci and at 2 engineered KCNQ2 target sites carrying different mutations.
PRJNA1533475 | ENA
UnknownMeiosis specific coiled-coil proteins in Shizosaccharomyces pombe.
Not available
S-EPMC1885245 | biostudies-literature
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