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TranscriptomicsSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-58657 | biostudies-arrayexpress
TranscriptomicsComparison of mouse epithelial tumor initiating cells to mesenchymal tumor initiating cells generated by EMT
The differentiation of stem-like cells of tumors may contribute to the cellular heterogeneity of breast cancers. We report the propagation of highly enriched mouse mammary cancer stem cells that retain the potential to differentiate both in vivo and in culture and their use to identify chemical com...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-33433 | biostudies-arrayexpress
ProteomicsMutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
Expansion of the poly-glutamine (Q) tract in the protein Huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we e...
ORGANISM(S): Homo sapiens (Human) 
2024-06-21 | PXD041846 | Pride
Huntington’s disease Huntingtin (htt) Brain development 
UnknownBroad repetitive transcranial magnetic stimulation (rTMS) of the precuneus in Alzheimer's disease: A rationale and study design.
Not available
S-EPMC11891574 | biostudies-literature
TranscriptomicsscRNA-seq of vertebrobasilar aneurysm in polyarteritis nodosa patient
Endovascular biopsy and fluorescence activated cell sorting was used to enrich for viable endothelial cells (ECs) from a vertebrobasilar aneurysm and the femoral artery. scRNAseq was then performed on 24 aneurysmal endothelial cells and 23 patient-matched non-aneurysmal femoral artery endothelial ce...
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-10681 | biostudies-arrayexpress
UnknownC-terminal turn stability determines assembly differences between Aβ40 and Aβ42.
Not available
S-EPMC3540122 | biostudies-literature
UnknownRepetitive transcranial magnetic stimulation for the treatment of drug-resistant epilepsy: A systematic review and individual participant data meta-analysis of real-world evidence.
Not available
S-EPMC5839309 | biostudies-literature
UnknownEffects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
Not available
S-EPMC2583320 | biostudies-literature
UnknownSerine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.
Not available
S-EPMC7324193 | biostudies-literature
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
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