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TranscriptomicsMyocilin regulates cell proliferation and survival by activating the ERK pathway
Myocilin, a causative gene for open-angle glaucoma, encodes a secreted glycoprotein of unknown function. To elucidate its function(s), we produced a stably transfected HEK293 cell line expressing myocilin and compared the expression profiles between the myocilin-expressing cell line and a vector con...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-53985 | biostudies-arrayexpress
TranscriptomicsIdentification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. We employed the Affymetrix platform to analyze the whole-...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-55260 | biostudies-arrayexpress
TranscriptomicsAge-related changes in gene expression in retinal microglia
In order to evaluate the gene expression profile of retinal microglia cells in different age, we purified CD11b-positive microglia from the retinas of wild type C57BL/6 mice at 3, 12, 18, and 24 months age using cell sorting method with flow cytometry. Age-related genes from isolated retinal microg...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-38739 | biostudies-arrayexpress
TranscriptomicsDistinct signature of altered homeostasis in aging rod photoreceptors: Implications for retinal diseases
To better understand the mechanistic basis of aging and its relationship with retinal degeneration, we examined gene expression changes in aging rod photoreceptors. Rod photoreceptor cell death is a feature of normal retinal aging and is accelerated in many retinal degenerative diseases, including A...
ORGANISM(S): Mus musculus 
2010-06-14 | E-GEOD-22317 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling of peripheral Qa-1 class Ib-restricted CD8aa+TCRab+ regulatory T Cells reveals innate-like features: implications for immune regulatory repertoire
To better understand the function of CD8aa Tregs, we have recently characterized several CD8aa+TCRab+ T cell clones and lines that are physiologically primed and are involved in recovery and protection from EAE (REF). In this report, we present a comparison of global gene expression patterns in CD8a...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-22985 | biostudies-arrayexpress
TranscriptomicsConditional ablation of the Notch2 receptor in the ocular lens
Notch signaling is essential for proper lens development, however the specific requirements of individual Notch receptors has not been previously investigated. Here we report the lens phenotypes of Notch2 conditionally mutant mice, which exhibited severe microphthalmia, reduced pupillary openings, d...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-31643 | biostudies-arrayexpress
TranscriptomicsPreservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina
Cone photoreceptors are the primary initiator of visual transduction in the human retina. Dysfunction or death of rod photoreceptors precedes cone loss in many retinal and macular degenerative diseases, suggesting a rod-dependent trophic support for cone survival. Rod differentiation and homeostasis...
ORGANISM(S): Mus musculus 
2011-11-15 | E-GEOD-33674 | biostudies-arrayexpress
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