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TranscriptomicsRNA-seq analysis of the transcriptome from Sulfur Deprivation Chlamydomonas cells
The Chlamydomonas reinhardtii transcriptome was characterized from nutrient-replete and sulfur-depleted wild-type and snrk2.1 mutant cells; the mutant is null for the regulatory serine-threonine kinase SNRK2.1, which is required for acclimation to sulfur deprivation. The transcriptome analyses invol...
ORGANISM(S): Chlamydomonas reinhardtii 
2010-07-07 | E-GEOD-17970 | biostudies-arrayexpress
GenomicsGenome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency
Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and is important for the erasure of imprints and epimutations, and the return to pluripotency. The extent of this reprogramming and its molecular mechanisms are poorly under...
ORGANISM(S): Mus musculus 
2010-01-26 | E-GEOD-19960 | biostudies-arrayexpress
GenomicsRelationship between nucleosome positioning and DNA methylation: Bisulfite-Seq, ChIP-Seq, and Mnase-Seq
Nucleosomes compact and regulate access to DNA in the nucleus, and are composed of approximately 147 bases of DNA wrapped around a histone octamer. Here we report a genome-wide nucleosome positioning analysis of Arabidopsis thaliana utilizing massively parallel sequencing of mononucleosomes. By com...
ORGANISM(S): Homo sapiens 
2010-05-29 | E-GEOD-21821 | biostudies-arrayexpress
GenomicsConservation and divergence of methylation patterning in plants and animals
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. While DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNA methylation appear to vary drastically among different organisms. Here, we used shotgun genomic bisulfite ...
ORGANISM(S): Ciona intestinalis 
2010-04-09 | E-GEOD-21152 | biostudies-arrayexpress
GenomicsMORC family ATPases required for heterochromatin condensation and gene silencing
Transposable elements (TEs) and DNA repeats are commonly targeted by DNA and histone methylation to achieve epigenetic gene silencing. We isolated mutations in two Arabidopsis genes, CRT1 and CRH6, which cause de-repression of DNA-methylated genes and TEs, but no losses of DNA or histone methylatio...
ORGANISM(S): Arabidopsis thaliana 
2012-05-02 | E-GEOD-37644 | biostudies-arrayexpress
TranscriptomicsSystems analysis of Chlamydomonas Cu nutrition reveals connections between Cu and multiple O2-dependent metabolic steps
We used digital gene expression (NlaIII sequence tags) and RNA-Seq to compare the transcriptomes of Cu-replete vs. Cu–deficient Chlamydomonas wild-type cells to reveal dozens of mRNAs whose abundance is modified. Half of the corresponding genes are targets of CRR1, a master regulator of nutritional ...
ORGANISM(S): Chlamydomonas reinhardtii 
2011-10-23 | E-GEOD-25124 | biostudies-arrayexpress
TranscriptomicsRelationship between nucleosome positioning and DNA methylation: ChIP-chip
Nucleosomes compact and regulate access to DNA in the nucleus, and are composed of approximately 147 bases of DNA wrapped around a histone octamer1, 2. Here we report a genome-wide nucleosome positioning analysis of Arabidopsis thaliana utilizing massively parallel sequencing of mononucleosomes. By...
ORGANISM(S): Arabidopsis thaliana 
2010-05-28 | E-GEOD-21818 | biostudies-arrayexpress
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