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ProteomicsImpact of whole-body versus nose-only exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model [Lung data]
The objective of this study was to compare the biological and toxicological response of apolipoprotein E-deficient (Apoe-/-) mice to 3R4F mainstream smoke exposure for 2 months in whole-body exposure chambers (WBEC) and nose-only exposure chambers (NOEC). Female ApoE-/- mice were randomized into fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-26 | PXD018185 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsA 7-month e-vapor aerosol inhalation toxicology study in C57BL/6 mice [Lung data]
A 7-month inhalation study in C57BL/6 mice was conducted to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation or switching to an e-vapor product after 3 months of exposure to 3R4F cigarette smoke (CS). In this study,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-31 | PXD019918 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
TranscriptomicsTranscription profiling of SrcR388A/Y527F or SrcD386N/Y527F stably transfected SYF cells serum-starved overnight and then treated with imidazole 5 mM for 1 h or 12 reveals that the protein tyrosine kinase Src R388A mutant can be rescued in live cells using the small molecule imidazole
SrcR388A/Y527F or SrcD386N/Y527F stably transfected SYF cells were serum-starved overnight and then treated with imidazole 5 mM for 1 h or 12 h. RNeasy Miniprep column (Qiagen) was used to prepare total RNA from each treatment group. All samples were run in commercial arrays from Affymetrix,
ORGANISM(S): Mus musculus 
2007-12-12 | E-GEOD-4043 | biostudies-arrayexpress
UnknownCBP binding outside of promoters and enhancers in Drosophila melanogaster.
Not available
S-EPMC4657240 | biostudies-literature
TranscriptomicsTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. An histone/protein acetyltransferase (HAT), p300, was recently found important for Treg function and stability, but further insights into the mechanisms by which p300 o...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60318 | biostudies-arrayexpress
UnknownCBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.
Not available
S-EPMC5826544 | biostudies-literature
GenomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-Seq
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20530 | biostudies-arrayexpress
TranscriptomicsIdentification of Sox9-Regulated Pathways During the Secondary Transition Stage of Pancreas Development
Sox9 target genes were identified during the secondary transition stage of pancreas development by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis. Sox9 was conditionally ablated during the secondary transition in the developing pancreas via recombinati...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-28670 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium bovis with pYUB412 and pRD1-2F9 genes knocked-in to investigate the ESX-1 secretion system
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 kDa culture filtrate protein CFP-10, and is missing from the vaccine strains M.bovis BCG and M.microti. Here, we systematically ...
ORGANISM(S): Mycobacterium bovis 
2007-01-30 | E-BUGS-31 | biostudies-arrayexpress
UnknownDetailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study.
Not available
S-EPMC7035231 | biostudies-literature
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