Sort   by:  
 Page size 
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
TranscriptomicsMouse Prostate Developmental Timecourse
Studies centered at the intersection of embryogenesis and carcinogenesis have identified striking parallels involving signaling pathways that modulate both developmental and neoplastic processes. In the prostate, reciprocal interactions between epithelium and stroma are known to influence neoplasia ...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-19225 | biostudies-arrayexpress
TranscriptomicsCellular adhesion promotes prostate cancer cells escape from dormancy
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, following initial treatment, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Iden...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-64262 | biostudies-arrayexpress
TranscriptomicsAR variant ARv567es induces carcinogenesis in a novel transgenic mouse model of prostate cancer.
Androgen deprivation therapy remains the primary treatment modality for patients with metastatic prostate cancer but is uniformly marked by progression to castration-resistant prostate cancer (CRPC) after a period of regression. Continued activation of androgen receptor (AR) signaling is attributed ...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-61303 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Field Effect
In this study, comparison of gene expression profiles in benign epithelia from men with prostate cancer to those of men without prostate cancer reveal differences in several genes associated with prostate cancer. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used ...
ORGANISM(S): Homo sapiens 
2010-10-18 | E-GEOD-24171 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Gene Expression Changes after Treatment with Neoadjuvant Dutasteride
To identify molecular changes underlying the chemopreventive or tumor promoting effects of SRD5A inhibition, we profiled gene expression changes in benign prostate epithelium from patients with PCa treated with dutasteride, a dual SRD5A inhibitor. Subjects were aged 45-80 years with clinically local...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9972 | biostudies-arrayexpress
TranscriptomicsThe Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment
Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate including benign prostatic hyperplasia (BPH) and prostate carcinoma. However, to date, there is no established molecular explanation for the age-dependent increases in these pathol...
ORGANISM(S): Mus musculus 
2010-09-15 | E-GEOD-21542 | biostudies-arrayexpress
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Gene Expression Changes with Neoadjuvant Hormone Therapy
Men with clinically localized prostate cancer were treated with 0 to 9 months of neoadjuvant hormone suppression prior to prostatectomy. Keywords: microarray, hormone, 9 men with prostate cancer were assigned to neoadjuvant hormone suppression therapy for 3-6, 6, or 0 months.
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9983 | biostudies-arrayexpress
Sort   by:  
 Page size