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TranscriptomicsGene expression analysis in a variety of normal, premalignant and squamous cell carcinomas of the cervix
We sought to apply the technologies of gene expression profiling to detect genes significant in the aetiology of cervical carcinoma . We investigated 14 normal (NAD), 11 low grade squamous intrapepithelial lesions (LSIL), 21 high grade squamous intraepithelial lesions (HSIL) and 28 squamous cell ca...
ORGANISM(S): Homo sapiens 
2013-09-17 | E-GEOD-27678 | biostudies-arrayexpress
TranscriptomicsAn integrated genomics approach for novel biomarker discovery in squamous cell cervical carcinoma
Detection of copy number dependent gene expression profiles in epithelial tumours has lead to the discovery of genes significant in diagnosis, prognosis and of therapeutic value. We sought to apply the technologies of gene expression profiling and copy number aberration detection by high density oli...
ORGANISM(S): Homo sapiens 
2011-03-05 | E-GEOD-27673 | biostudies-arrayexpress
UnknownAtypical serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma.
Not available
S-EPMC3626496 | biostudies-literature
TranscriptomicsLow dose ionizing radiation treated lymphoblastoid cells
Irradiated cell lines exposed to 1-10 Gy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1, 2.5, 5, 7.5, 10 Gy, RNA is isolated and labeled using a T7 amplification Arcturus kit for hybridization on triplicate arrays.
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22639 | biostudies-arrayexpress
TranscriptomicsFunctional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles
Although gain of chromosome-5p is one of the most frequent DNA copy number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross-sectional clinical study we showed that the microRNA processor Drosha (located on chromoso...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-26177 | biostudies-arrayexpress
TranscriptomicsFunctional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles [mRNA]
Comparison of mRNA expression profiles in W12 Series 1 cervical ectokeratinocytes at passage number 22 versus 19 (during which time the cells gain an invasive phenotype) As these cells demonstrate gain of chromosome 5p during this time, mRNA expression profiling data interrogated for over-expressed ...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-26176 | biostudies-arrayexpress
TranscriptomicsReplenishing co-downregulated miR-100-5p and miR-125b-5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption.
Illumina bead array data from TCam2, 1411H, and 2102Ep cell lines for mRNA expression. Cell lines were treated with either mismatch negative control (MNC) or combination miRNA replenishment with equimolar concentration of miR-100-5p and miR-125b-5p. Five comparisons are provided; namely TCam2 cell l...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13464 | biostudies-arrayexpress
TranscriptomicsFunctional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles [miRNA]
Comparison of miRNA expression profiles in cervical carcinoma cell lines to study the effects of Drosha expression levels Analyzed global miRNA expression profiles from 18 samples (7 samples in duplicate, 4 single sample) representing cervical carcinoma cell lines with either relative Drosha over-e...
ORGANISM(S): Homo sapiens 
2011-05-25 | E-GEOD-26175 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumour cells release microRNA containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Malignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bl...
ORGANISM(S): Homo sapiens 
2023-09-30 | E-MTAB-13322 | biostudies-arrayexpress
TranscriptomicsMalignant Germ Cell Tumors Display Common microRNA Profiles Resulting in Global Changes in Expression of mRNA Targets
Comparison of miRNA expression profiles in malignant germ cell tumors compared to non-malignant control group. Use of bioinformatic algorithm Sylamer to interrogate mRNA expression profiles from malignant germ cell tumors for enrichment or depletion of binding sites for differentially expressed miRN...
ORGANISM(S): Homo sapiens 
2010-03-14 | E-GEOD-18155 | biostudies-arrayexpress
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