Sort   by:  
 Page size 
ProteomicsPolymyxin resistance in colibactin-producing Escherichia coli induces host genotoxicity
The complex reservoir of metabolite-producing bacteria in the gastrointestinal tract contributes tremendously to human health and disease. Bacterial composition, and by extension gut metabolomic composition, is undoubtably influenced by the use of modern antibiotics. Herein, we demonstrate that poly...
ORGANISM(S): Escherichia coli 
2021-07-15 | PXD025088 | Pride
Escherichia coli Colibactin Antimicrobial resistance 
ProteomicsThe Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links
Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the progression of colorectal cancer and inflammatory bowel disease. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links (ICLs) tha...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-11 | PXD055646 | Pride
Interstrand cross-link Colibactin Xenopus laevis 
GenomicsNUS Colibactin Project
Gut metagenomes of Mice from NUS Colibactin Project
PRJEB64247 | ENA
OtherColibactin DNA damage signature indicates mutational impact in colorectal cancer
Colibactin, a potent genotoxin of Escherichia coli, causes DNA double strand breaks (DSBs). We investigated if colibactin creates a particular DNA damage signature in infected human cells. Genomic contexts of colibactin-induced DSBs were enriched for a distinct AT-rich hexameric sequence motif. A su...
ORGANISM(S): Homo sapiens 
2020-04-22 | GSE145594 | GEO
GenomicsEffect of colibactin on gastroesophageal adenocarcinoma
Colibactin-producing E. coli promote carcinogenesis of gastroesophageal adenocarcinoma
PRJEB102277 | ENA
GenomicsColibactin DNA damage signature indicates mutational impact in colorectal cancer
Colibactin DNA damage signature indicates mutational impact in colorectal cancer
PRJNA607699 | ENA
GenomicsEscherichia coli K1 colibactin
The genotoxin colibactin is a determinant of virulence in Escherichia coli K1 experimental neonatal systemic infection
PRJEB9141 | ENA
TranscriptomicsColibactin-driven colon cancer requires adhesin-mediated epithelial binding
Various bacteria are suggested to contribute to colorectal cancer (CRC) development, including pks+ E. coli, which produces the genotoxin colibactin that induces characteristic mutational signatures in host epithelial cells. However, it remains unclear how the highly unstable colibactin molecule is ...
ORGANISM(S): Mus musculus 
2024-08-19 | GSE241851 | GEO
GenomicsColibactin-driven colon cancer requires adhesin-mediated epithelial binding
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding
PRJNA1010330 | ENA
UnknownOxygen concentration modulates colibactin production.
Not available
S-EPMC10269391 | biostudies-literature
Sort   by:  
 Page size