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Proteomicssalivary duct carcinoma genomics
Salivary duct carcinoma is a rare and aggressive salivary gland cancer subtype with poor prognosis. Its mutational landscape has been described rather exhaustively but little is known regarding its functional genomics and tumor microenvironment. In this study, we combined transcriptomics and proteom...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015885 | Pride
Salivary gland 
TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in plasma using High Resolution mass spectrometry (MS). This labeling approach could be of great interest for monitoring many leucine-co...
ORGANISM(S): Homo Sapiens 
2025-11-10 | PXD046373 | panorama
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in cerebrospinal fluid (CSF) and in plasma using targeted mass spectrometry (MS). This labeling approach could be of great interest for ...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD046142 | panorama
ProteomicsModeling the simultaneous dynamics of proteins in blood plasma and the cerebrospinal fluid in human in vivo
The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling such as in Alzheimer disease, and to provide informative data regarding drug efficacy, or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net...
ORGANISM(S): Homo Sapiens 
PXD047851 | panorama
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