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Glucocorticoids are widely used therapeutically to suppress inflammatory/immune responses and most of their effects are produced either by altering transcription of specific genes directly, or by altering the expression of transcription factors that subsequently alter the expression of downstream ge...
ORGANISM(S): Rattus norvegicus 
Pancreatic islet isolation for single-cell RNA sequencing (scRNA-seq) requires extensive enzymatic and mechanical processing that may affect cell recovery and transcriptional state. We evaluated a practical gradient-free workflow for murine pancreatic islets from diabetic BKS.Cg-Dock7^m +/+ Lepr^db/...
ORGANISM(S): Mus musculus 
2026-09-30 | GSE347182 | GEO
Bone metabolism is a dynamic process involving osteoblasts, osteoclasts, and osteocytes, which maintain skeletal integrity through continuous remodelling. Disruptions in this homeostasis – caused by mineral or hormonal imbalances, systemic metabolic or inflammatory conditions, or genetic predisposit...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-13 | PXD056459 | Pride
Identification of the inflammatory signature in visceral adipose tissue CD14+ cells (adipose tissue macrophage) Total RNA obtained from CD14+ cells (Immunoselcted cells from stromal adipose tissue cells) Adipocytes and cells of the stroma vascular fraction (SVF) were obtained by collagenase digestio...
ORGANISM(S): Homo sapiens 
Identification of the inflammatory signature in visceral adipose tissue CD14+ cells (adipose tissue macrophage) Total RNA obtained from CD14+ cells (Immunoselcted cells from stromal adipose tissue cells) Adipocytes and cells of the stroma vascular fraction (SVF) were obtained by collagenase digestio...
ORGANISM(S): Homo sapiens 
Extracellular vesicles (EVs) have gained significant attention as potential diagnostic and therapeutic tools due to their role in intercellular communication and their ability to encapsulate various biomolecules. However, the isolation of EVs from tissue remains challenging, often requiring enzymati...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-11-07 | PXD045737 | Pride
Background: The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling. Methods: The gene expression profile of patients (n=37) with oral tongue SCC were analyzed using Affyme...
ORGANISM(S): Homo sapiens 
In this research we have done a comprehensive transcripteome analysis of hESC differentiation at three different stages: early neural differentiation, neural ectoderm, and mature neurons. We detected and validated time-dependent gene expression patterns and represented that the gene expression patte...
ORGANISM(S): Homo sapiens 
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