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ProteomicsMouse brain-derived extracellular vesicles proteomics
P2x purinoreceptor 7 (P2RX7), an ATP gated ion-channel, is known to play a role in extracellular vesicles (EV) secretion. In this study we performed mass spectrometry of extracellular vesicles isolated from brain tissues (brain-derived EVs, BDEVs) of 9.5-months-old WT, PS19 and PS19/P2rx7-/- mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-22 | PXD065057 | Pride
Mouse Brain Extracellular vesicles Lc-ms/ms 
ProteomicsEfficient enzyme-free isolation of brain-derived extracellular vesicles
Extracellular vesicles (EVs) have gained significant attention as potential diagnostic and therapeutic tools due to their role in intercellular communication and their ability to encapsulate various biomolecules. However, the isolation of EVs from tissue remains challenging, often requiring enzymati...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-11-07 | PXD045737 | Pride
Collagenase-free protocol Prion protein Brain-derived evs Bdevs 
ProteomicsEarly life exposure to deltamethrin impairs synaptic function by altering the brain derived extracellular vesicle proteome
Pyrethroid pesticides, widely used in agriculture and households, have been associated with neurodevelopmental disorders including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). While behavioral effects of pyrethroid exposure have been previously reported, the un...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-24 | PXD052521 | Pride
Neurodevelopment Hippocampus Pyrethroid Hebbian plasticity Exosome 
TranscriptomicsStatus Epilepticus Alters the Function of Brain-Derived Extracellular Vesicles [N2A-RNA-Seq]
Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments. Mesial temporal...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE327585 | GEO
GenomicsStatus Epilepticus Alters the Function of Brain-Derived Extracellular Vesicles [miRNA_10Day]
Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments. Mesial temporal...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE327584 | GEO
GenomicsStatus Epilepticus Alters the Function of Brain-Derived Extracellular Vesicles [miRNA-24hr]
Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments. Mesial temporal...
ORGANISM(S): Mus musculus 
2026-06-18 | GSE327583 | GEO
TranscriptomicsSmall RNA sequencing of brain-derived extracellular vesicles from post-mortem brain tissue of controls and Alzheimer's disease patients with different APOE genotypes
Using a recently optimized method for separation of brain-derived EVs (bdEVs) from post-mortem tissues, we obtained bdEVs of 23 AD patients with different APOE genotypes and 7 controls. RNA was extracted from brain homogenate, an intermediate ("10K") EV fraction, and more purified EVs and subjected ...
ORGANISM(S): Homo sapiens 
2020-10-20 | GSE159541 | GEO
ProteomicsComprehensive analysis of proteins encapsulated in brain-derived extracellular vesicles (BDEVs) from mice subjected to acute stress.
Brain-derived extracellular vesicles (BDEVs) were isolated from serum from acutely stressed and control mice by a combination of ultracentrifugation and immunoprecipitation, and a comprehensive analysis of the proteins contained within was performed.
ORGANISM(S): Mus Musculus (mouse) 
2025-05-30 | PXD052683 | JPOST Repository
UnknownRNA Landscapes of Brain and Brain-Derived Extracellular Vesicles in Simian Immunodeficiency Virus Infection and Central Nervous System Pathology.
Not available
S-EPMC11095537 | biostudies-literature
UnknownAssessing the Nature of Human Brain-Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air-liquid Microfluidic Platform.
Not available
S-EPMC12786325 | biostudies-literature
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