Sort   by:  
 Page size 
TranscriptomicsThe S-adenosyl-homosteine hydrolase inhibitor DZNeP unspecifically affects histone methylation patterns in embryos and results in developmental aberrations
3-deazaneplanocin A (DZNeP) is a promising cancer drug affecting the methylation status of histone lysine residues. To investigate the specificity and mode of action of DZNeP, zebrafish embryos displaying high histone methyltransferase activity were cultured with DZNeP and histone methylation (H3K4m...
ORGANISM(S): Danio rerio 
2014-11-21 | E-GEOD-53209 | biostudies-arrayexpress
TranscriptomicsMapping of H3K4 and H3K27 trimethylation in zebrafish cells (ChIP-chip)
The genomic distribution of post-translationally modified histones in the zebrafish (Danio rerio) genome remain largely unraveled. The objective of this study was to (1) design a microarray covering all zebrafish gene promoters and 5' end of coding regions, and (ii) using these arrrays, map the geno...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-23691 | biostudies-arrayexpress
TranscriptomicsMapping of H3K4 and H3K27 trimethylation in zebrafish cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-23872 | biostudies-arrayexpress
TranscriptomicsMarking of the genome by H3K4 methylation prior to embryonic gene activation
Early zebrafish embryo development proceeds first from a maternally transcribed and stored mRNAs, and zygotic gene activation (ZGA) is initiated at the mid-blastula transition (MBT; 1000-cell stage), 3.3 h post-fertilization. Very little is known on how the zygotic genome is programmed for transcr...
ORGANISM(S): Danio rerio 
2011-12-02 | E-GEOD-27314 | biostudies-arrayexpress
TranscriptomicsMapping of H3K4 and H3K27 trimethylation in zebrafish cells (Gene expression)
The genomic distribution of post-translationally modified histones in the zebrafish (Danio rerio) genome remain largely unraveled. The objective of this study was to (1) design a microarray covering all zebrafish gene promoters and 5' end of coding regions, and (ii) using these arrrays, map the geno...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-23679 | biostudies-arrayexpress
TranscriptomicsEpigenetic environment of histone H3.3 on promoters revealed by integration of imaging, ChIP-chip, and MeDIP-chip data
Epigenetic environment of histone H3.3 on promoters revealed by integration of imaging and genome-scale chromatin and methyl-DNA immunoprecipitation information. Chromatin regions with different transcriptional outputs are distinguished by the deposition of histone variants. Histone H3.3 is incorpor...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-17053 | biostudies-arrayexpress
TranscriptomicsSpatially restricted position-dependent implications of lamin A promoter occupancy on gene activity (ChIPs and MeDips)
Interactions between the nuclear lamina (NL) and chromatin are thought to occur through large lamin association domains (LADs) and correlate with gene repression in these domains. We show that binding of lamin A/C (LMNA) to promoters occurs on discrete domains that are associated with distinct trans...
ORGANISM(S): Homo sapiens 
2013-07-14 | E-GEOD-42522 | biostudies-arrayexpress
TranscriptomicsDNA methylation in progenitor cells
This SuperSeries is composed of the following subset Series: GSE19773: DNA methylation in progenitor cells: expression study GSE19794: DNA methylation in progenitor cells: MeDIP study Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-19795 | biostudies-arrayexpress
TranscriptomicsDevelopmental features of DNA methylation during activation of the embryonic zebrafish genome
Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in zebrafish and is a period of chromatin remodeling. Genome-scale gametic demethylation and remethylation occurs after fertilization, during blastula stages, but how ZGA relates to promoter DNA methylation states is unknown...
ORGANISM(S): Danio rerio 
2012-07-05 | E-GEOD-33236 | biostudies-arrayexpress
TranscriptomicsDNA methylation in progenitor cells: MeDIP study
We surveyed DNA methylation profiles of all human RefSeq promoters in relation to gene expression and differentiation in adipose tissue, bone marrow and muscle mesenchymal progenitors, as well as in bone marrow-derived hematopoietic progenitors. We unravel strongly overlapping DNA methylation profil...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-19794 | biostudies-arrayexpress
Sort   by:  
 Page size