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MetabolomicsExtracts from sweet sorghum (Sorghum bicolor), a feedstock for biorefining, suppressed proliferation and elevated apoptosis in human colon cancer stem cells via suppression of Wnt/beta-catenin signaling pathway
In colorectal cancer, p53 is commonly inactivated, associated with chemo-resistance, and marks the transition from non-invasive to invasive disease. Cancers, including colorectal cancer, are thought to be diseases of aberrant stem cell populations, as stem cells are able to self-renew, making them l...
2014-05-01 | MTBLS69 | MetaboLights
TranscriptomicsSPROUTY2 target genes in human colon carcinoma cells
The role of SPROUTY2 (SPRY2) in human colon cancer is controversial. Our data support a tumorigenic action of SPRY2. We use microarrays to identify SPRY2 target genes in human SW480 ADH colon carcinoma cell line. RNA was obtained from SW480 ADH cells, Mock transfected or transfected with WT or two d...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-56941 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of SIM2s in human RKO colon carcinoma cells in a timecourse
RKO Colon Carcinoma Cells were treated with 100nM of either SIM2s Control or Antisense oligos in a timecourse (10, 14, 18, 24hr) dependent manner.
ORGANISM(S): Homo sapiens 
2004-11-01 | E-MEXP-101 | biostudies-arrayexpress
TranscriptomicsColon tumor samples
In response to polarization cues, cultured Caco-2 cells, a human colon adenocarcinoma-derived cell line, form a polarized epithelium resembling normal enterocytes. We investigated potential signaling mechanisms activated by Caco-2 cells that might trigger the genome-wide transcriptional reprogrammi...
ORGANISM(S): Homo sapiens 
2007-08-17 | E-GEOD-7466 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiles of 84 colon adenocarcinomas and paired nontumorous
The goal of this study was to identify microRNAs that were differentially expressed in colon tumors and determine if microRNA expression profiles could predict poor cancer survival. Keywords: disease state design For these experiments, we used RNA extracted from pairs of colon adenocarcinoma tissue ...
ORGANISM(S): Homo sapiens 
2008-02-12 | E-GEOD-7828 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of methotrexate-treated human colon cancer C85 cells
The experiment was aimed at identification of genes whose expression is upregulated in human colon cancer C85 cells during the process of establishment of methotrexate-induced senescence.
ORGANISM(S): Homo sapiens 
2011-08-23 | E-MEXP-3018 | biostudies-arrayexpress
TranscriptomicsAll exon array expression data in normal colon and primary colon cancer lines [expression]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns. Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36400 | biostudies-arrayexpress
GenomicsEpigenomic enhancer profiling defines a signature of colon cancer [ChIP-seq]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns.  Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36204 | biostudies-arrayexpress
TranscriptomicsEpigenomic enhancer profiling defines a signature of colon cancer
This SuperSeries is composed of the following subset Series: GSE36204: Epigenomic enhancer profiling defines a signature of colon cancer [ChIP-seq] GSE36400: All exon array expression data in normal colon and primary colon cancer lines [expression] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36401 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in colorectal carcinoma samples compared to normal human colon
To globally define methylation-’prone’ and -’protected’ CpG islands in colorectal carcinoma we analyzed the methylation status of 23,000 CpG islands of the human genome in ten coleorectal carcinoma samples as well as normal colon using our previously described methyl-CpG immunoprecipitation ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17512 | biostudies-arrayexpress
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