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TranscriptomicsSca-1 expression defines different developmental stages of mouse PDC that show functional heterogeneity in the endosomal but not lysosomal TLR9 response
Plasmacytoid dendritic cells (PDC) play an important role in innate and adaptive immunity and were shown to be identical to previously described natural IFN-M-NM-1-producing cells (NIP). Here, we describe two functionally distinct PDC subpopulations that are characterized by the differential express...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-42860 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and TREM2 deficient microglia in a mouse model of Alzheimer's disease
We examined the role of TREM2 on microglia responses to amyloid-beta deposition in a mouse model of Alzheimer's disease Microglia were FACS-purified from 8.5 month old WT, Trem2-/-, 5XFAD, and Trem2-/- 5XFAD mice
ORGANISM(S): Mus musculus 
2015-03-13 | E-GEOD-65067 | biostudies-arrayexpress
GenomicsDistinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells [ChIP-seq & ATAC-seq]
Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been studied extensively in model organisms, little is kn...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-77299 | biostudies-arrayexpress
TranscriptomicsDistinct Gene Regulatory Pathways for Human Innate Versus Adaptive Lymphoid Cells [gene expression]
Innate lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory mediators, rapidly communicating danger via cytokine secretion, and functioning as guardians of tissue homeostasis. Although ILCs have been studied extensively in model organisms, little is kn...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-78896 | biostudies-arrayexpress
TranscriptomicsA host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyc...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-16943 | biostudies-arrayexpress
UnknownHigh affinity interactions and signal transduction between Aβ oligomers and TREM2
Not available
S-SCDT-EMM-2018-09027 | biostudies-other
UnknownUnderstanding Barriers Impacting upon Patient Wellbeing: A Nationwide Italian Survey and Expert Opinion of Dermatologists Treating Patients with Moderate-to-Severe Psoriasis.
Not available
S-EPMC10779771 | biostudies-literature
UnknownA draft human pangenome reference.
Not available
S-EPMC10172123 | biostudies-literature
UnknownPan-conserved segment tags identify ultra-conserved sequences across assemblies in the human pangenome.
Not available
S-EPMC10475782 | biostudies-literature
UnknownRecombination between heterologous human acrocentric chromosomes.
Not available
S-EPMC10172130 | biostudies-literature
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