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GenomicsGene body 5-hydroxymethylcytosine facilitates transcription in olfactory neurons
The modified DNA base 5-hydroxymethylcytosine (5hmC) is enriched in neurons where it may contribute to gene function and cellular identity. To address this issue in an in vivo neuronal population, we assessed the patterning, stability, and function of the base within gene bodies in olfactory sensory...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-43617 | biostudies-arrayexpress
TranscriptomicsThe developmental patterning of 5-hydroxymethylcytosine during neuronal differentiation
Recent analyses of 5-hydroxymethylcytosine (5hmC) suggest that the modified base influences transcription by acting as an intermediate to demethylation. However, elevated levels of 5hmC within neural tissues suggest that the mark is stable and may directly contribute to gene regulation. Here, we cha...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-38604 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional landscapes of Dnmt3a-deficient olfactory sensory neurons
During differentiation, neurons experience a reorganization of DNA modification patterns within their genomes. However, the mechanisms underlying this developmental patterning and its role in defining the neurona­­l state are currently unclear. Here, we find that the d­­e novo DNA methyltransfer...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-52464 | biostudies-arrayexpress
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