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MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
MetabolomicsUnveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: A comparative study with Saccharomyces cerevisiae BY4742

This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative gr...

2024-10-04 | MTBLS10757 | MetaboLights
MetabolomicsIntegrated Metabolomics, Transcriptomics, and Functional Validation Reveal Oxidoreductase-Associated Strictinin Accumulation in Assam tea Germplasm
Strictinin, a bioactive hydrolyzable tannin in tea, accumulates at high levels in some Assam tea germplasms, yet the molecular basis underlying its variation remains unclear. Here, a rapid LC-MS/MS method was established for strictinin quantification and applied to profile 157 Assam tea accessions, ...
2026-08-03 | MTBLS14896 | MetaboLights
MetabolomicsIntegrated metabolomics and transcriptomics analysis elucidate the candidate genes for polyphyllin biosynthesis in Paris

Polyphyllins are the key components in Paris, with varying levels and compositions among different species. This study investigated polyphyllin compositions of 206 Paris samples from 16 different producing areas. 9 Paris polyphylla var. yunnanensis, 3 Paris fargesii and 3 Paris forrestii were sel...

2024-10-18 | MTBLS10682 | MetaboLights
MetabolomicsBiodiversity in marine invertebrate responses to acute warming revealed by a comparative multi-omics approach
Understanding species' responses to environmental change underpins our abilities to make predictions on future biodiversity under any range of scenarios. In spite of the huge biodiversity in most ecosystems, a model species approach is often taken in environmental studies. To date, we still do not k...
2016-06-23 | MTBLS336 | MetaboLights
MetabolomicsIntegrated Four Comparative-Omics Reveals the Mechanism of the Terpenoid Biosynthesis in Two Different Overwintering Cryptomeria fortunei Phenotypes
Chinese cedar (Cryptomeria fortunei) is a tree species with important ornamental, medicinal, and economic value. Terpenoids extracted from the essential oil of C. fortunei needles have been considered valuable ingredients in the pharmaceutical and cosmetic industries. However, the poss...
2022-08-12 | MTBLS3183 | MetaboLights
MetabolomicsComparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...
2025-07-09 | MTBLS9800 | MetaboLights
TranscriptomicsRegeneration of comparative genomic hybridization oligonucleotide microarrays with dimethylurea
Reuse of materials in DNA hybridization based methods has been known since the advent of Southern membranes. Array based comparative genomic hybridization is essentially Southern hybridization with multiple probes immobilized on a solid surface. We have shown that comparative genomic hybridization m...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35740 | biostudies-arrayexpress
TranscriptomicsNetwork-based analysis of carbohydrate-active gene transcription in Aspergillus niger
Transcriptomics was performed on batch cultivations of A. niger grown on three monosaccharides and three complex carbohydrates with defined compositions as to allow the detection of cross-induction if present, and for demonstration of how enzyme interaction graphics can be used to visualize the glob...
ORGANISM(S): Aspergillus niger 
2012-03-28 | E-GEOD-11930 | biostudies-arrayexpress
GenomicsNepenthes comparative transcriptomics
comparative transcriptomics in Nepenthes pitcher plants
PRJEB37797 | ENA
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