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ProteomicsA post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
We compared hESCs with their neuronal counterpart to quantify differences in the expression of cold-shock domain containing proteins. While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modula...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD007738 | Pride
Comparison hescs versus their differentiated counterparts 
ProteomicsComparison non-targeting hRNA hESCs versus UBE2K shRNA hESCs
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018625 | Pride
Histones Ubiquitin proteasome system Hescs 
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