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TranscriptomicsExpression data from human embryonic stem cells(hESCs)
To detect the effect of early culture on hESCs, almost all initial-passaged hESCs have normal expression of DLK1-DIO3 gene cluster, the low-passaged hESCs lost the expression of DLK1-DIO3 gene cluster. hESCs were extracted for RNA with TriZOL and hybridization on Affymetrix arrays
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-38662 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human cardiac progenitors and cardiomyocytes generated from embryonic bodies, directed differentiation of hESCs with PDGFa or co-culturing hESCs with END2 cell line.
Human cardiomyocytes can be generated from human embryonic stem cells (hESCs) in vitro by a variety of methods, including co-culture with visceral endoderm-like cell lines and growth factor directed differentiation as monolayers or three-dimensional embryonic bodies. To enable the identification, pu...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-MEXP-3371 | biostudies-arrayexpress
ProteomicsComparison non-targeting hRNA hESCs versus UBE2K shRNA hESCs
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018625 | Pride
Histones Ubiquitin proteasome system Hescs 
GenomicsChromatin and Transcriptional Signatures for Nodal Signaling During Endoderm Formation in hESCs
To elucidate the Nodal transcriptional network that governs endoderm formation, we used ChIP-Seq to identify genomic targets for SMAD2/3, SMAD3, SMAD4, FOXH1 and the active and repressive chromatin marks, H3K4me3 and H3K27me3, in human embryonic stem cells (hESCs) and derived endoderm. We demonstrat...
ORGANISM(S): Homo sapiens 
2011-05-21 | E-GEOD-29422 | biostudies-arrayexpress
TranscriptomicsExpression data from H9 human embryonic stem cells (hESCs) differentiated to Early Mesoendoderm
We used microarrays to detail the global programme of gene expression during early hESC differentiation to Mesendoderm using FBS. Samples of hESCs were taken at undifferentiated state (0h), 8h of differentiation, 24h of differentiation, and 72h of differentiation with three replicates (A, B, and C) ...
ORGANISM(S): Homo sapiens 
2016-03-22 | E-GEOD-74004 | biostudies-arrayexpress
TranscriptomicsCardiac precursor differentiation from hESCs by lentiviral promoter drug selection
Several of the essential core transcriptional control elements in human embryonic stem cells (ESCs) have been identified, but the production and function of alternative isoforms in self-renewal, pluripotency and tissue lineage specification remain largely unknown. We have modified the H9 ESC line to...
ORGANISM(S): Homo sapiens 
2008-10-24 | E-GEOD-13297 | biostudies-arrayexpress
TranscriptomicsX-inactivation in hESCs
X chromosome inactivation (XCI) is a dosage compensation mechanism in female cells to regulate X-linked gene expression. We report here that subcultures from established lines of female hESCs displayed variations (0-100%) in the expression of XCI markers such as XIST RNA coating and enrichment of h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9637 | biostudies-arrayexpress
GenomicsHomo sapiens strain:HUES8 hESCs
HUES8 TET1/2/3 TKO hESCs RNA Sequencing
PRJNA352092 | ENA
TranscriptomicsRNA-Seq of 3iL human embryonic stem cells
Human embryonic stem cells (hESCs) are isolated from the inner cell mass of the blastocysts. The pluripotent properties of hESCs enable the derivation of cell-types or tissues of different lineages for potential applications such as therapeutics discovery and regenerative medicine. Even though hES...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-2031 | biostudies-arrayexpress
TranscriptomicsComparison of hiPSCs, hESCs and fibroblasts
In our study, PRDM14 and NFRkB were found to enhance the reprogramming of human fibroblasts to hiPSCs in the presence of OCT4, SOX2, KLF4, with/without c-MYC (OSK/OSKC). To examnie if the obtained hiPSC share similar expression signature with hESC, we conducted the microarray analysis on the hiPSCs,...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-22792 | biostudies-arrayexpress
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