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ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
UnknownComplexin-1 and synaptotagmin-1 compete for binding sites on membranes containing PtdInsP2.
Not available
S-EPMC9515229 | biostudies-literature
UnknownComplexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions.
Not available
S-EPMC3854000 | biostudies-literature
UnknownSynaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin.
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S-EPMC6733930 | biostudies-literature
UnknownSynergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.
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S-EPMC7220375 | biostudies-literature
UnknownAnalysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.
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S-EPMC9811660 | biostudies-literature
UnknownComplexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology.
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S-EPMC4510914 | biostudies-literature
UnknownComplexin-1 regulated assembly of single neuronal SNARE complex revealed by single-molecule optical tweezers.
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S-EPMC9905088 | biostudies-literature
UnknownEvolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins.
Not available
S-EPMC5445133 | biostudies-literature
UnknownComplexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex.
Not available
S-EPMC4927292 | biostudies-literature
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