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MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
ProteomicsMechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog
Escherichia coli (E. coli) urinary tract infections (UTIs) are becoming a serious problem both for pets and humans (zoonosis) due to the close contact and to the increasing resistance to antibiotics. Great progress has been made in the discovery of novel antibiotics to counteract E. coli pathogens. ...
ORGANISM(S): Escherichia coli 
2015-06-05 | PXD002000 | Pride
Escherichia coli Enrofloxacin Antibiotic resistance Urinary tract infections 
UnknownCARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database.
Not available
S-EPMC7145624 | biostudies-literature
UnknownNCRD: A non-redundant comprehensive database for detecting antibiotic resistance genes.
Not available
S-EPMC10590964 | biostudies-literature
ProteomicsAcetyl-proteome profiling of Staphylococcus aureus revealed lysine acetylation in bacterial antibiotic resistance
Protein post-translational modifications (PTMs) play crucial roles in various biological processes across prokaryotes and eukaryotes. Lysine acetylation (Kac), which is observed in different bacteria species and is known to be a dynamic and reversible PTM involved in numerous physiological functions...
ORGANISM(S): Staphylococcus aureus 
2024-10-17 | PXD043277 | Pride
Post-translational modification  staphylococcus aureus  antibiotic resistance  lysine acetylation  ribosome 
ProteomicsPotential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Antibiotic resistance is increasingly becoming a serious challenge to public health. The regulation of metabolism by post-translational modifications (PTMs) has been widely studied; however, the comprehensive mechanism underlying the regulation of acetylation in bacterial resistance against antibiot...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2022-10-14 | PXD030283 | Pride
Post-translational modification  escherichia coli  acetylation  pykf  antibiotic resistance 
UnknownCARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database.
Not available
S-EPMC9825576 | biostudies-literature
UnknownDetection of Antimicrobial Resistance Using Proteomics and the Comprehensive Antibiotic Resistance Database: A Case Study.
Not available
S-EPMC7378939 | biostudies-literature
ProteomicsA Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
Gram-negative bacterial infections are causing increasing levels of morbidity due to the rise of resistance to established antibiotics. New antibiotic classes with distinct molecular mode of action are therefore required. Recently, a family of macrocyclic peptidomimetics was discovered that target t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2018-06-21 | PXD008577 | Pride
Dia Thermo q-exactive plus Pseudomonas Peptidomimetic antibiotic Lpt complex Gram-negative bacteria Photo crosslinking Molecular mode of action Lc-ms/ms 
UnknownCapturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes.
Not available
S-EPMC7187591 | biostudies-literature
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