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ProteomicsLower H2S-generating enzyme levels and persulfidation-mediated protein protection characterize metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction–associated steatohepatitis (MASH), marked by hepatic steatosis and inflammation, is a major risk for cirrhosis and liver cancer. Obesity-induced oxidative stress plays a central role in MASH promoting protein damage and dysfunction. Cysteine persulfidation (PSSH), a post-transl...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD057932 | Pride
Phosphoproteomics Cxcr4 oligomerization Apoptosis Lc-ms/ms 
ProteomicsMetabolic dysfunction-associated steatohepatitis reduces hepatic H2S- producing enzymes altering persulfidome composition
Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven byobesity-related hepatic inflammation and oxidative stress. Recently, cysteine persulfidation (PSSH), a protective post-translational modification by hydrogen sulfide (H2S), was established to play a role in red...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD066952 | Pride
Persulfidome Obesity Mash 
UnknownMetabolic dysfunction-associated steatohepatitis reduces hepatic H<sub>2</sub>S-producing enzymes altering persulfidome composition.
Not available
S-EPMC12421645 | biostudies-literature
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