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ProteomicsPersulfidome of A549 alveolar epithelial cells
To better define the relationship between persulfidation and the cellular antifungal response, we analyzed the cellular persulfidome (proteome of persulfidated proteins) in A549 and in CTH-/- cells upon challenge with Aspergillus fumigatus conidia and/or the sulfide donor GYY4137. All proteins were ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD076106 | Pride
Aspergillus fumigatus A549 persulfidome Gyy4137 persulfidome Cth-/- 
ProteomicsMetabolic dysfunction-associated steatohepatitis reduces hepatic H2S- producing enzymes altering persulfidome composition
Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven byobesity-related hepatic inflammation and oxidative stress. Recently, cysteine persulfidation (PSSH), a protective post-translational modification by hydrogen sulfide (H2S), was established to play a role in red...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD066952 | Pride
Persulfidome Obesity Mash 
UnknownDietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner.
Not available
S-EPMC7979915 | biostudies-literature
ProteomicsTST knockout liver proteome iTRAQ and persulfidome
Impaired hepatic glucose and lipid metabolism are hallmarks of type–2 diabetes. Increased sulfide production or sulfide–donor compounds may beneficially regulate hepatic metabolism. Disposal of sulfide through the sulfide oxidation pathway (SOP) is critical for maintaining sulfide within a safe phy...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD028909 | Pride
Persulfidome Liver Proteome Mouse Tst Msms 
ProteomicsErgothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing extension of lifespan and enhanced mobility in Caenorhabditis elegans, accompan...
ORGANISM(S): Caenorhabditis elegans 
2025-01-21 | PXD051587 | Pride
Ergothioneine Healthspan Persulfidation Hydrogen sulfide Nad 
ProteomicsLower H2S-generating enzyme levels and persulfidation-mediated protein protection characterize metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction–associated steatohepatitis (MASH), marked by hepatic steatosis and inflammation, is a major risk for cirrhosis and liver cancer. Obesity-induced oxidative stress plays a central role in MASH promoting protein damage and dysfunction. Cysteine persulfidation (PSSH), a post-transl...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD057932 | Pride
Phosphoproteomics Cxcr4 oligomerization Apoptosis Lc-ms/ms 
UnknownPersulfidome of Sweet Pepper Fruits during Ripening: The Case Study of Leucine Aminopeptidase That Is Positively Modulated by H2S
Not available
S-EPMC11200738 | biostudies-literature
UnknownMetabolic dysfunction-associated steatohepatitis reduces hepatic H<sub>2</sub>S-producing enzymes altering persulfidome composition.
Not available
S-EPMC12421645 | biostudies-literature
UnknownHydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms.
Not available
S-EPMC8355753 | biostudies-literature
UnknownSulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release.
Not available
S-EPMC12578401 | biostudies-literature
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